59310-31-5

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 
• 131-58-8 2-Methylbenzophenone 

Downstream Products

• 52839-46-0 2-(2-benzoylbenzyl)isoindoline-1,3-dione 
• 349148-01-2 2,3-dihydro-3-hydroxy-2-[2-hydroxyphenylmethylphenylmethyl]-1H-isoindol-1-one 
• 1415505-60-0 2-(acryloylamino)-N-(4-benzoylbenzyl)-N,N-dimethylethanaminium bromide 
• 191093-15-9 N-(4-benzoylbenzyl)-2-(methacryloyloxy)-N,N-dimethylethanaminium bromide 
• 1137728-05-2 diethyl 2-benzoylphenylmethylphosphonate 

Relevant academic research and scientific papers

Novel high-activity diphenyl ketone photoinitiator and preparation method thereof

The invention belongs to the field of photosensitive high polymer materials, and provides a novel high-activity diphenyl ketone photoinitiator. Two diphenyl ketone derivatives are synthesized into a novel diphenyl ketone photoinitiator through synthesis reaction, so that ultraviolet absorption wavelength and absorption peak area of the photoinitiator are increased, a utilization rate on ultraviolet light is increased, the photoinitiating activity is greatly improved, and range of application is increased. The invention provides a preparation method for the novel diphenyl ketone photoinitiator,and the preparation method is simple in reaction process, is gentle in reaction condition, is simple in post-treatment, and is easy to purify.

MALONONITRILE OXIME ETHER COMPOUND AND USE THEREOF

Disclosed is a malononitrile oxime ether compound having a novel structure as shown in the general formula I. Respective substituents in the general formula I as defined in the specification. The compound of the general formula I exhibits an excellent microbicidal activity, and can effectively prevent and treat plant diseases caused by bacteria and fungi. Also provided is a use of the compound of the general formula I as a microbicide in the agricultural and other fields.

Enantioselective Synthesis of Indolines, Benzodihydrothiophenes, and Indanes by C?H Insertion of Donor/Donor Carbenes

We employ a single catalyst/oxidant system to enable the asymmetric syntheses of indolines, benzodihydrothiophenes, and indanes by C?H insertion of donor/donor carbenes. This methodology enables the rapid construction of densely substituted five-membered rings that form the core of many drug targets and natural products. Furthermore, oxidation of hydrazones to the corresponding diazo compounds proceeds in situ, enabling a relatively facile one- or two-pot protocol in which isolation of potentially explosive diazo alkanes is avoided. Regioselectivity studies were performed to determine the impact of sterics and electronics in donor/donor metal carbene C?H insertions to form indolines. This methodology was applied to a variety of substrates in high yield, diastereomeric, and enantiomeric ratios and to the synthesis of a patented indane estrogen receptor agonist with anti-cancer activity.

NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

New pyrazole derivatives having CRTh2 antagonistic behaviour

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

An expedient synthesis of poly-substituted 1-arylisoquinolines from δ-ketonitriles via indium-mediated Barbier reaction protocol

We developed an efficient synthetic strategy of poly-substituted 1-arylisoquinolines via an indium-mediated Barbier type allylation from δ-ketonitriles. Initial attack of allylindium species occurred at the nitrile group selectively to form the enamine intermediate, which reacted with the ketone group intramolecularly to furnish the isoquinolines.

Imidazolylmethylbenzophenones as highly potent aromatase inhibitors

Suppression of tumor and plasma estrogen levels by inhibition of aromatase is one of the most effective treatments for post-menopausal breast cancer patients. Starting from an easy, synthetically accessible, benzophenone scaffold, a new class of potent aromatase inhibitors was synthesized, endowed with high selectivity with respect to 17α-hydroxylase/17,20-lyase (CYP17). Compounds 1b and 1d proved to be among the most potent inhibitors described so far.

Novel cyclic amide derivatives

Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an aryl group, a heterocyclic group or the like; Q represents a group represented by —CH2—, —CO—, —O—, —CH(OR7)— or the like wherein R7 represents a hydrogen atom, an alkyl group or the like; n represents an integer of from 0 to 5; R1 and R2 each represent a hydrogen atom, an alkyl group or the like; B represents either of the following groups: wherein R3, R4, R5, and R6 each represent a hydrogen atom, a halogen atom, an alkoxyl group or the like; m represents 1 or 2; and the ring of: represents an aromatic heterocyclic ring.

Intramolecular addition of a hydroxyl to a N-acyliminium system. Application to the synthesis of isoindolo[2,1-a] [3,1]benzoxazine and isoindolo[1,2-c][2,4] benzoxazepine derivatives

The titled compounds were prepared by the reaction of hydroxylated lactam (3a-c) or (10) with p-toluenesulfonic acid in dichloromethane. The ratio of diastereomeric mixtures (4b/5b (2/1) or 4c/5c (2/1) or 11/12 (5/1)) is discussed.

Synthesis of 11-Phenyl-6H-dibenzo[b,f][1,4]oxazocine and 11-Phenyl-6H-dibenzo[b,f][1,4]thiazocine 1

A convenient synthesis of 11-phenyl-6H-dibenzo[b,f] [1,4]oxazocine 1 and the corresponding thiazocine 2 is described.