349150-53-4

Upstream product

• 20763-19-3 (methoxymethylene)triphenylphosphorane 
• 77123-58-1 2-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 5159-41-1 2-iodobenzyl alcohol 
• 229027-92-3 {2-[2-(trimethylsilyl)ethynyl]phenyl}methanol 
• 1066-54-2 trimethylsilylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 349150-55-6 1-(2-trimethylsilanylethynyl-phenyl)-but-3-en-2-ol 
• 90-14-2 1-Iodonaphthalene 
• 23833-70-7 (E)-1-(3,4-dimethoxystyryl)naphthalene 
• 104784-51-2 1-(trimethylsilyl)ethynylnaphthalene 

Relevant academic research and scientific papers

Catalytic Cyclization of o-Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3-Benzazepines

A novel osmium-catalyzed cyclization of o-alkynyl phenethylamines to give 3-benzazepines is reported. The procedure allows the straightforward preparation of a broad range of dopaminergic 3-benzazepine derivatives. Mechanistic investigations revealed that the process takes place via osmacyclopropene intermediates, which were isolated and characterized by X-ray crystallography.

Syntheses of 12H-benzo[a]xanthen-12-ones and benzo[a]acridin-12(7H)-ones through Au(i)-catalyzed Michael addition/6-endo-trig cyclization/aromatization cascade annulation

A multifaceted gold(i)-catalyzed aromaticity-driven double 6-endo cascade cyclization strategy to synthesize both 12H-benzo[a]xanthen-12-ones and benzo[a]acridin-12(7H)-ones, whose core motifs xanthone and acridone both exist as important scaffolds in an

Palladium(II)-Catalyzed Cascade Reactions of Ene-Ynes Tethered to Cyano/Aldehyde: Access to Naphtho[1,2- b]furans and Benzo[ g]indoles

An efficient palladium(II)-catalyzed cascade reaction of ene-yne substrates carrying cyano/aldehyde group is described. It involves successive hetero- and benz-annulations in one pot via trans-oxo/aminopalladation onto alkyne, followed by 1,2-addition to

An Unprecedented, Lewis Acid-Mediated, Metal-Free Iodoannulation Strategy to Aromatic Iodides

A direct transformation of ortho-alkynylated aromatic vinyl ethers to 1-iodonaphthalenes and other iodo-heterocycles under mild Lewis acidic conditions in the presence of iodide as an external nucleophile is reported. The first example of an iodoannulation strategy using a nucleophilic source of iodine, coupled with good to excellent yields, exclusive alpha regioselectivity and a broad substrate scope makes this work an attractive avenue towards the construction of aromatic iodides.

Gold-catalyzed oxidative cycloadditions to activate a quinoline framework

Going for gold! Gold-catalyzed reactions of 3,5- and 3,6-dienynes with 8-alkylquinoline oxides results in an oxidative cycloaddition with high stereospecificity (see scheme; EWG = electron-withdrawing group); this process involves a catalytic activation o

Synthetic study of the angular tetracyclic core skeleton of landmycine a via Masamune-Bergman cyclization

We describe the synthesis, via Masamune-Bergman cyclization, of an angucycline derivative involving a quinone in the B ring and a nonaromatic hydroxylated C ring. The naphthoquinone was synthesized via the copper-catalyzed Ullmann reaction of the dihalo a

Palladium(0)-catalyzed alkylative cyclization of alkynals and alkynones: Remarkable trans-addition of organoboronic reagents

Palladium/monophosphine complexes catalyze trans-selective arylative, alkenylative, and alkylative cyclization reactions of alkynals and alkynones with organoboronic reagents. These reactions afford six-membered allylic alcohols with endo-tri- or tetrasub

Diastereoselective Pauson-Khand reactions on aromatic substrates

The synthesis of several natural products' frameworks is carried out by means of a diastereoselective intramolecular Pauson-Khand reaction promoted by molecular sieves. Diastereoselectivity is achieved only if a coordinating group is present at a convenie