34916-94-4

Basic information

• Product Name: (R)-2-methyl-3-phenyl-propionitrile
• CAS NO: 34916-94-4
• Molecular Weight: 145.204
• Mol File: 34916-94-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-methyl-3-phenyl-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-methyl-3-phenyl-propionitrile(34916-94-4)
• EPA Substance Registry System: (R)-2-methyl-3-phenyl-propionitrile(34916-94-4)

Safety Data

• Hazardous Substances Data: 34916-94-4(Hazardous Substances Data)

Upstream product

• 53334-59-1 (S)-1-phenylpropan-2-yl 4-methylbenzenesulfonate 
• 143-33-9 sodium cyanide 
• 75-05-8 acetonitrile 
• 104-53-0 3-phenyl-propionaldehyde 
• 123-38-6 propionaldehyde 

Relevant articles and documents

Asymmetric synthesis of α-substituted nitriles and cyanohydrins by oxidative cleavage of chiral aldehyde hydrazones with magnesium monoperoxyphthalate

Optically active α- and α,β-substituted aldehyde hydrazones 2, 4, and 7, which are readily available by assymmetric alkylation, Michael addition or [2,3]-Wittig rearrangement of chiral hydrazones can be transformed into nitriles 3 and 5 or cyanohydrins 8 by MMPP mediated oxidation, respectively. This synthetic sequence offers a C-C connective entry into optically active functionalised nitriles with good overall yields (30-75%) together with high diastereo- and enantioselectivities (de = 76 - ≥ 96%, ee ≥ 72 - ≥ 97%).