34918-74-6

Upstream product

• 7472-54-0 N-(p-methoxyphenyl)benzamide 
• 104-94-9 4-methoxy-aniline 
• 98-88-4 benzoyl chloride 

Downstream Products

• 36640-74-1 1-[N-(4-methoxy-phenyl)-benzimidoyl]-3,5-dimethyl-1H-pyrazole 
• 36664-33-2 methyl 1--5-methyl-3-pyrazolecarboxylate 
• 60566-20-3 N,N'-bis(4-methoxyphenyl)benzimidamide 
• 425366-02-5 N-(4-methoxy-phenyl)-benzimidic acid 4-cyano-phenyl ester 
• 27228-22-4 N-(4-methoxy-phenyl)-benzimidoyl isothiocyanate 
• 22751-79-7 1,3-diphenylbenzo[e]-[1,2,4]triazin-7(1H)-one 
• 857589-27-6 2-(N-benzoyl-p-anisidino)-5-chloro-benzoic acid 
• 857589-26-5 2-(N-benzoyl-p-anisidino)-5-chloro-benzoic acid methyl ester 
• 17282-70-1 6-methoxy-2-phenylquinolin-4-ol 
• 873383-41-6 4-hydroxy-6-methoxy-2-phenyl-quinoline-3-carboxylic acid 
• 37856-17-0 3-(4-methoxyphenyl)-2-phenyl-(3H)-quinazolin-4-one 
• 1137746-68-9 diethyl α-(p-anisylimino)benzylphosphonate 
• 1073486-94-8 3-phenyl-2-(4-methoxybenzyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one 
• 1160218-74-5 allyl N-(4-methoxyphenyl)benzimidate 

Relevant academic research and scientific papers

Synthesis of N-Hydroxy-N-(o-chlorophenyl)-N'-(p-methoxyphenyl)benzamidine Hydrochloride and Its Reactions with Various Metal Ions

A new reagent N-hydroxy-N-(o-chlorophenyl)-N'-(p-methoxyphenyl)benzamidine hydrochloride, has been synthesized and is characterized on the basis of mp, elemental analysis, IR and UV spectra.The reactions of the reagent with metal ions suggest that new met

Synthesis of Imidoyl Chlorides Using Phosphorus Trichloride

Abstract: The reaction of carboxamides with phosphorus trichloride under heating at 75–80°C for 1 h in the presence of a 4-dimethylaminopyridine catalyst was used to synthesize imidoyl chlorides in yields of 63–99%.

Acylation of 2-benzylpyridine N-oxides and subsequent in situ [3,3]-sigamatropic rearrangement reaction

An effective method for the acylation of 2-benzylpyridine N-oxides and their fast in situ [3,3]-sigmatropic rearrangement was reported. This transformation has a wide substrate scope under mild conditions, giving moderate to excellent yields. The application for the synthesis of chiral phenyl-2-pyridylmethanol products was briefly explored. Furthermore, an interesting example of tandem substitution and in situ [3,3]-sigamatropic rearrangement of 2-benzylpyridine N-oxide with benzenecarboximidoyl chloride was reported.

Synthesis of Nitrogen-Containing Polyaromatics by Aza-Annulative π-Extension of Unfunctionalized Aromatics

Nitrogen-containing polycyclic aromatic compounds (N-PACs) are an important class of compounds in materials science. Reported here is a new aza-annulative π-extension (aza-APEX) reaction that allows rapid access to a range of N-PACs in 11–84 % yields from readily available unfunctionalized aromatics and imidoyl chlorides. In the presence of silver hexafluorophosphate, arenes and imidoyl chlorides couple in a regioselective fashion. The follow-up oxidative treatment with p-chloranil affords structurally diverse N-PACs, which are very difficult to synthesize. DFT calculations reveal that the aza-APEX reaction proceeds through the formal [4+2] cycloaddition of an arene and an in situ generated diarylnitrilium salt, with sequential aromatizations having relatively low activation energies. Transformation of N-PACs into nitrogen-doped nanographenes and their photophysical properties are also described.

α-Imino Iridium Carbenes from Imidoyl Sulfoxonium Ylides: Application in the One-Step Synthesis of Indoles

Imidoyl sulfoxonium ylides are presented for the first time as potential precursors to generate α-imino metal-carbene intermediates and applied in direct C-H functionalization reactions catalyzed by [Ir(cod)Cl]2 (4 mol %) to provide 2-substituted indoles (up to 70% yield) in just one step. This class of sulfur ylide is successfully obtained from imidoyl chloride and dimethylsulfoxonium methylide (23 new examples in 45-85% yield) or by imino group formation from the corresponding β-keto sulfoxonium ylides and anilines in the presence of TiCl4 as a Lewis acid (9 examples in 33-94% yield).

Domino 1,4- And 1,6-Addition Reactions of Ketene Silyl Acetals to Dialkynyl Imines Promoted by Aluminum Chloride: Synthesis of Multifunctionalized β-Lactams

Domino 1,4- and 1,6-addition reactions of ketene silyl acetals to dialkynyl imines are disclosed. Aluminum chloride promoted domino 1,4- and 1,6-addition reactions of ketene silyl acetals to dialkynyl imines to give a variety of alkenyl iminocyclobutenones in moderate to good yields. The chemoselective reduction of alkenyl iminocyclobutenones and the subsequent thermal rearrangement of resulting alkenyl aminocyclobutenones in the presence of appropriate amines provided cis or trans multifunctionalized β-lactams in moderate to high yields with good to high diastereoselectivities.

Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines

A single-pot procedure for the synthesis of 2,4-diarylquinazolines is described which involves a silver oxide-mediated C–H activation/C–N bond formation process. The generality of this method with respect to substituent effects is presented along with studies leading to process optimization. Mechanistic investigations provide support for the involvement of radical intermediates in the reaction process.

Efficient synthesis of tertiary acyclic amides by the Chapman rearrangement of aryl benzimidates in ionic liquids

The Chapman rearrangement of aryl N-arylbenzimidates to tertiary acyclic amides is accelerated in ionic liquids and proceeds at lower temperatures as 120-190°C.

Solvent/oxidant-switchable synthesis of multisubstituted quinazolines and benzimidazoles via metal-free selective oxidative annulation of arylamidines

A fast and simple divergent synthesis of multisubstituted quinazolines and benzimidazoles was developed from readily available amidines, via iodine(III)-promoted oxidative C(sp3)-C(sp2) and C(sp 2)-N bond formation in nonpolar and polar solvents, respectively. Further selective synthesis of quinazolines in polar solvent was realized by TEMPO-catalyzed sp3C-H/sp2C-H direct coupling of the amidine with K2S2O8 as the oxidant. No metal, base, or other additives were needed.

5-Imino-1,2,4-thiadiazoles: First small molecules As substrate competitive inhibitors of glycogen synthase kinase 3

Cumulative evidence strongly supports that glycogen synthase kinase-3 (GSK-3) is a pathogenic molecule when it is up-dysregulated, emerging as an important therapeutic target in severe unmet human diseases. GSK-3 specific inhibitors might be promising effective drugs for the treatment of devastating pathologies such as neurodegenerative diseases, stroke, and mood disorders. As GSK-3 has the ability to phosphorylate primed substrates, small molecules able to bind to this site should be perfect drug candidates, able to partially block the activity of the enzyme over some specific substrates. Here, we report substituted 5-imino-1,2,4-thiadiazoles as the first small molecules able to inhibit GSK-3 in a substrate competitive manner. These compounds are cell permeable, able to decrease inflammatory activation and to selectively differentiate neural stem cells. Overall, 5-imino-1,2,4-thiadiazoles are presented here as new molecules able to decrease neuronal cell death and to increase endogenous neurogenesis blocking the GSK-3 substrate site