34932-33-7Relevant academic research and scientific papers
Molecular modelling and synthesis of quinazoline-based compounds as potential antiproliferative agents
Said Ali Yassen, Asmaa,Eldin Abd Elhamed Ahmed Elshihawy, Hosam,Mokhtar Amin Said, Mohamed,Abouzid Mohamed Abouzid, Khaled
, p. 454 - 466 (2014/05/20)
In this study, four series of 4-anilinoquinazoline derivatives were designed and synthesized as potential anti-proliferative agents. Mechanism of anticancer activity was explained through molecular docking of the target compounds into epidermal growth factor receptor tyrosine kinase (EGFR-TK) active site which displayed comparable binding mode of certain compounds to that of lapatinib. Moreover, the newly synthesized compounds were tested for their anti-proliferative activity on breast carcinoma cell line (MCF-7). 6-(4-Ben-zylpiperazin-1-ylsulfonyl)-4-(4-bromoanilino)quinazoline (14g) exhibited the most potent inhibitory activity (IC50=5.52 μM).
