349410-94-2

Basic information

• Product Name: (4-nitro-phenyl)-acetic acid ethylamide
• Synonyms: (4-nitro-phenyl)-acetic acid ethylamide
• CAS NO: 349410-94-2
• Molecular Weight: 208.217
• Mol File: 349410-94-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-nitro-phenyl)-acetic acid ethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (4-nitro-phenyl)-acetic acid ethylamide(349410-94-2)
• EPA Substance Registry System: (4-nitro-phenyl)-acetic acid ethylamide(349410-94-2)

Safety Data

• Hazardous Substances Data: 349410-94-2(Hazardous Substances Data)

Upstream product

• 75-04-7 ethylamine 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 104-03-0 4-nitrobenzeneacetic acid 

Relevant articles and documents

Anticonvulsant activity of some 4-aminophenylacetamides

A series of 4-aminophenylacetamides was prepared and evaluated for anticonsulvant activity. These compounds were prepared during studies designed to determine the relationship between benzamide-like compounds and anticonsulvant effects. Unlike benzamides, these phenylacetamides have a methylene group between the aromatic ring and the amide carbonyl. Consequently, formal conjugation is lost, and the number of conformational degrees of freedom has increased. The compounds were tested in mice against seizures induced by electroshock and pentylenetetrazol, and in the rotorod assay for neurologic deficit. The more active and selective anticonsulvants prepared in this study were those having an additional aromatic ring as part of the substituent on the amide nitrogen. Compound 16, the 4-aminophenylacetamide derived from 2,6-dimethylaniline, was the most potent compound observed (ED50 = 50.50 mg/kg against electroshock-induced convulsions and ED50 = 93.20 mg/kg against pentylenetetrazol-induced convulsions).