349416-85-9

Upstream product

• 76-02-8 trifluoroacetyl chloride 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 1228763-36-7 N-(2-trifluoromethylphenyl)dichloroacetimidoyl chloride 
• 1228757-53-6 N-(2-trifluoromethylphenyl)-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl) dichloroacetimidate 

Relevant academic research and scientific papers

α-Halogenoacetanilides as hydrogen-bonding organocatalysts that activate carbonyl bonds: Fluorine versus chlorine and bromine

α-Halogenoacetanilides (X=F, Cl, Br) were examined as H-bonding organocatalysts designed for the double activation of Ci￡O bonds through NH and CH donor groups. Depending on the halide substituents, the double H-bond involved a nonconventional Ci-H×××O in

N-aryl-O-glycosyl haloacetimidates as glycosyl donors

Reaction of 1-O-unprotected tetra-O-acetyl- and tetra-O-benzyl- glucopyranose with N-aryl haloacetimidoyl chlorides in the presence of sodium hydride and 15-crown-5 afforded N-aryl-O-glucopyranosyl haloacetimidates. Mainly the β-anomers were obtained in this anomeric O-acylation-type reaction. The glycosyl donor properties of these haloacetimidates were investigated with 6-O- and 4-O-unprotected glucopyranosides as acceptors. The results were compared with those obtained with the corresponding O-glucopyranosyl trichloroacetimidates as glycosyl donors and the same acceptors. It was found that N-(2-chloro-6-methylphenyl)-O-glucopyranosyl trifluoroacetimidates (16Ad, 16Bd) exhibit glycosyl donor properties closely related to those of the corresponding N-unsubstituted O-glucopyranosyl trichloroacetimidates (12A, 12B). Copyright Taylor & Francis Group, LLC.