349428-85-9

Usage

Uses

Used in Pharmaceutical Research and Development:
2-(4-Bromophenyl)-1-morpholinoethanone is utilized as an intermediate in the synthesis of pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents. Its unique structural features allow it to be a key component in creating molecules with specific biological activities.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-(4-Bromophenyl)-1-morpholinoethanone is employed for the creation of a wide range of organic molecules. Its ability to participate in various chemical reactions makes it a valuable asset in the synthesis of complex organic compounds.
Used in Medicinal Chemistry:
2-(4-Bromophenyl)-1-morpholinoethanone is studied for its potential pharmacological activities, such as its anti-inflammatory and analgesic properties. This research aims to explore and harness its therapeutic potential for the development of new medications.
Used in Chemical Research:
2-(4-Bromophenyl)-1-morpholinoethanone is also used in chemical research to understand and develop new reaction pathways and mechanisms, further expanding the scope of organic chemistry and its applications in various industries.

Upstream product

• 110-91-8 morpholine 
• 1436595-64-0 tert-butyl 4-bromophenylacetylenyl ether 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 

Downstream Products

• 736991-39-2 4-[2-(4-bromophenyl)ethyl]morpholine 
• 1092563-23-9 1-morpholin-4-yl-2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]ethanone 
• 1620955-81-8 C₃₂H₃₃N₅O₅ 
• 1620955-82-9 2-(4'-(2-morpholino-2-oxoethyl)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride 
• 1467061-23-9 6-chloro-5-{4-[2-(morpholin-4-yl)-2-oxoethyl]phenyl}-1H-indole-3-carbaldehyde 

Relevant academic research and scientific papers

Amidation reaction of carboxylic acid with formamide derivative using SO3?pyridine

The amidation reaction of carboxylic acid derivatives was developed using sulfur trioxide pyridine complex (SO3?py) as a commercially available and easily handled oxidant. This method could be applied to the reaction of various aromatic and aliphatic carboxylic acids, including optically active ones, with formamide derivatives to afford the corresponding amides in good to high yields.

Catalytic reductive N-alkylation of amines using carboxylic acids

We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.

SUBSTITUTED BENZAMIDES AND THEIR USES

Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use.

SMALL MOLECULE LFA-1 INHIBITORS

The present invention relates to novel compounds which are capable of inhibiting the interaction of LFA-1 with its counter ligands.

The ketene-surrogate coupling: Catalytic conversion of aryl iodides into aryl ketenes through ynol ethers

tert-Butoxyacetylene is shown to undergo Sonogashira coupling with aryl iodides to yield aryl-substituted tert-butyl ynol ethers. These intermediates participate in a [1,5]-hydride shift, which results in the extrusion of isobutylene and the generation of aryl ketenes. The ketenes are trapped in situ with multiple nucleophiles or undergo electrocyclic ring closure to yield hydroxynaphthalenes and quinolines.

METALLOENZYME INHIBITOR COMPOUNDS

The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

SUBSTITUTED BENZAMIDES AND THEIR USES

Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use.

Pd(II)-catalyzed synthesis of indoles from α-aryloxime O-pentafluorobenzoates via intramolecular aromatic C-H amination

α-Aryl-a-aminocarbonyloxime O-pentafluorobenzoates are found to be promising precursors for synthesis of 2 3-disubstituted indole derivatives catalyzed by PdCl2(MeCN)2 in the presence of MgO as a base. The reaction is supposed to pro