349471-99-4

Upstream product

• 244262-56-4 (Z)-6-Chloro-3-methyl-5-triisopropylsilanyloxy-hex-3-en-1-ol 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 349471-98-3 (+/-)-N-(6-chloro-3-methyl-5-triisopropylsiloxyhex-3-ene)-N-t-butoxycarbonyl-N-tosylamide 

Downstream Products

• 349479-00-1 (+/-)-(3Z,9E,11Z)-7-aza-1-chloro-4-methyl-12-(2-methoxycarbonyl-3,3-dimethoxy)cyclopentyl-7-p-toluenesulfonyl-2-triisopropylsiloxydodeca-3,9,11-triene 
• 349479-02-3 (+/-)-(3Z,9E,11Z)-7-aza-1-chloro-4-methyl-12-(2-methoxycarbonyl-3-oxo)cyclopentyl-7-p-toluenesulfonyl-2-triisopropylsiloxydodeca-3,9,11-triene 

Relevant academic research and scientific papers

Total synthesis of 3-azasteroids via the transannular Diels-Alder strategy

The total synthesis of four new 3-azasteroids is described, using the transannular Diels-Alder (TADA) reaction. Elaboration of the acyclic trienes, macrocyclizations and TADA reactions are detailed, as well as the stereochemical outcome of the reaction.