349472-86-2Relevant academic research and scientific papers
Modular pyridine-type P,N-ligands derived from monoterpenes: Application in asymmetric Heck addition
Malkov, Andrei V.,Bella, Marco,Stará, Irena G.,Ko?ovsky, Pavel
, p. 3045 - 3048 (2001)
Novel (diphenylphosphinophenyl)pyridine ligands (+)-8, (+)-15, (-)-21, and (-)-26 were synthesized from (-)-β-pinene, (+)-3-carene, (+)-2-carene, and (-)-α-pinene, respectively, via Kro?hnke annulation as the key step, and shown to effect ≤88% ee in Heck addition (27→28). Ligands (+)-15 and (-)-21 are quasi-enantiomeric; ligands 8 and 26 can be prepared in both enantiomeric forms from (+)- and (-)-enantiomers of α- and β-pinene, respectively.
