349487-03-2Relevant articles and documents
Enantioselective reduction of β-keto sulfones using the NaBH4/Me3SiCl system catalyzed by polymer-supported chiral sulfonamide
Zhao, Gang,Hu, Jian-bing,Qian, Zhan-shan,Yin, Wei-xing
, p. 2095 - 2098 (2002)
In the presence of 25 mol% of polymer-supported chiral sulfonamide, a variety of β-keto sulfones can be reduced into the corresponding β-hydroxy sulfones in excellent yields and with high enantioselectivities using the reducing system of NaBH4/
Efficient synthesis of chiral β-hydroxy sulfones: Via iridium-catalyzed hydrogenation
Tao, Lin,Yin, Congcong,Dong, Xiu-Qin,Zhang, Xumu
, p. 785 - 788 (2019/01/30)
A highly efficient Ir/f-Amphol-catalyzed asymmetric hydrogenation of prochiral β-keto sulfones was successfully developed to prepare a series of chiral β-hydroxy sulfones with good to excellent results (62%->99% conversions, 35%-99% yields and 86%->99% ee). Our Ir/f-Amphol L4 catalytic system exhibited very high activity; the gram-scale asymmetric hydrogenation was performed well with just 0.005 mol% catalyst loading (S/C = 20,000) to afford the desired product 2a with >99% conversion, 99% yield and 93% ee.
Asymmetric hydrogenation of β-keto sulfonamides and β-keto sulfones with a chiral cationic ruthenium diamine catalyst
Huang, Xiao-Fei,Zhang, Shao-Yun,Geng, Zhi-Cong,Kwok, Chun-Yuen,Liu, Peng,Li, Hai-Yan,Wang, Xing-Wang
, p. 2860 - 2872 (2014/03/21)
Optically active β-hydroxy sulfonamides and β-hydroxy sulfones are very important building blocks for the preparation of bioactive compounds and pharmaceuticals. In this work, a highly efficient asymmetric hydrogenation of β-keto sulfonamides and β-keto s
Enantioselective bioreduction of β-keto sulfones with the fungus Curvularia lunata
Gotor, Vicente,Rebolledo, Francisca,Liz, Ramon
, p. 513 - 515 (2007/10/03)
β-Keto sulfones bearing bulky groups are reduced with high enantioselectivities to the corresponding optically active β-hydroxy sulfones by the fungus Curvularia lunata CECT 2130; the cells can be re-used without loss of their catalytic activity.