34956-29-1Relevant academic research and scientific papers
INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
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, (2018/04/27)
The present disclosure discloses compounds capable of modulating the activity of α- amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity Relationship Study
Hansen, Stinne W.,Erichsen, Mette N.,Fu, Bingru,Bj?rn-Yoshimoto, Walden E.,Abrahamsen, Bjarke,Hansen, Jacob C.,Jensen, Anders A.,Bunch, Lennart
, p. 8757 - 8770 (2016/10/22)
Screening of a small compound library at the three excitatory amino acid transporter subtypes 1-3 (EAAT1-3) resulted in the identification of compound (Z)-4-chloro-3-(5-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic aci
OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY
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Page/Page column 68, (2015/01/07)
The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS
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Page/Page column 82, (2014/06/24)
The invention relates to novel compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
NOVEL COMPOUNDS
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Paragraph 0472; 0473, (2014/06/23)
Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction.
Making imines without making water - exploiting a recognition-mediated Aza-Wittig reaction
Del Amo, Vicente,Philp, Douglas
supporting information; experimental part, p. 301 - 304 (2009/07/04)
(Figure Presented) A recognition-mediated aza-Wittig reaction permits the efficient formation of an imine in dry CDCl3 from an iminophosphorane and an aldehyde. The kinetic and thermodynamic parameters for this reaction are compared with those
SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE
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Page/Page column 143-144, (2010/11/27)
Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.
SYNTHESIS OF A NOVEL MACROCYCLIC LACTONE SYSTEM
Smith, Keith,Morris, Ian K.,Bass, Robert J.
, p. 1865 - 1872 (2007/10/02)
A total synthesis of a 14-membered ring lactone (3) with potential biological activity is described.The final lactonization step uses a modification of the Corey pyridinethiol ester procedure.
