34956-30-4

Basic information

• Product Name: N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide
• CAS NO: 34956-30-4
• Molecular Formula: C₁₅H₂₀N₂O₂S
• Molecular Weight: 292.3965
• Mol File: 34956-30-4.mol
• Article Data: 2

Chemical Properties

• Density: 1.23g/cm³
• Refractive Index: 1.621
• CAS DataBase Reference: N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide(34956-30-4)
• EPA Substance Registry System: N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide(34956-30-4)

Safety Data

• Hazardous Substances Data: 34956-30-4(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 34956-31-5 N-(4-acetyl-3-methylphenyl)acetamide 

Downstream Products

• 34841-55-9 2-(4-amino-2-methylphenyl)acetic acid 

Relevant articles and documents

Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists

Activation of the nuclear farnesoid X receptor (FXR) which acts as cellular bile acid sensor has been validated as therapeutic strategy to counter liver disorders such as non-alcoholic steatohepatitis by the clinical efficacy of obeticholic acid. FXR antagonism, in contrast, is less well studied and potent small molecule FXR antagonists are rare. Here we report the systematic optimization of a novel class of FXR antagonists towards low nanomolar potency. The most optimized compound antagonizes baseline and agonist induced FXR activity in a full length FXR reporter gene assay and represses intrinsic expression of FXR regulated genes in hepatoma cells. With this activity and a favorable toxicity-, stability- and selectivity-profile it appears suitable to further study FXR antagonism in vitro and in vivo.