3496-81-9

Usage

Structure

Urea derivative with a cyclohexyl group and an isopropyl group attached to the nitrogen atom

Usage

Organic intermediate in the synthesis of pharmaceuticals and agrochemicals, corrosion inhibitor in water treatment processes, stabilizer in the production of plastics and rubber

Potential

Studied for its potential as an antitumor agent

Upstream product

• 34780-31-9 N-cyclohexyl-N'-isopropylthiourea 
• 563-83-7 ISOPROPYLAMIDE 
• 108-91-8 cyclohexylamine 
• 1122-56-1 cyclohexylcarboxamide 
• 75-31-0 isopropylamine 
• 92109-08-5 cyclohexylcarbamic acid 4-nitrophenyl ester 

Downstream Products

• 3496-83-1 N-cyclohexyl-N'-isopropylcarbodiimide 
• 3385-48-6 N¹-Isopropyl-N²-cyclohexyl-formamidin 

Relevant academic research and scientific papers

Highly efficient synthesis of ureas and carbamates from amides by iodosylbenzene-induced hofmann rearrangement

A simple and efficient method for the synthesis of 1,3-disubstituted ureas and carbamates from amides by using iodosylbenzene as the oxidant is described. Symmetric and asymmetric ureas and carbamates can be prepared by this procedure in up to 98 % yield. Ureidopeptides can also be prepared in good yield by this method. A simple and efficient method for the synthesis of 1,3-disubstituted ureas and carbamates from amides by using iodosylbenzene as the oxidant is described. By using this method, heterocyclic products can be easily obtained in excellent yield. Ureidopeptides can also be prepared in good yield by this procedure. Copyright

A New Convenient Method for the Synthesis of Symmetrical and Unsymmetrical N,N'-Disubstituted Ureas

A new method is described for the preparation of symmetrically and unsymmetrically disubstituted ureas by aminolysis of bis(4-nitrophenyl) carbonate.The second substitution is slower than the first one, and it is possible to isolate monosubstituted intermediates when equimolar amounts of substrates are used.The reaction of the intermediates with different amines give unsymmetrical derivatives of urea.