349628-87-1Relevant academic research and scientific papers
Amino acid catalyzed direct asymmetric aldol reactions: A bioorganic approach to catalytic asymmetric carbon-carbon bond-forming reactions
Sakthivel,Notz,Bui,Barbas III
, p. 5260 - 5267 (2001)
Direct asymmetric catalytic aldol reactions have been successfully performed using aldehydes and unmodified ketones together with commercially available chiral cyclic secondary amines as catalysts. Structure-based catalyst screening identified L-proline a
Additive-controlled regioselective direct asymmetric aldol reaction of hydroxyacetone and aldehyde
Liu, Ling-Yan,Wang, Bing,Zhu, Yunna,Chang, Wei-Xing,Li, Jing
, p. 533 - 542 (2013/06/27)
A structurally simple dipeptide derivative 1b prepared from l-proline and l-valine has been developed for the direct asymmetric aldol reaction of hydroxyacetone and various aldehydes with moderate to high yields and high enantioselectivities. More importa
(2S,5S)-Pyrrolidine-2,5-dicarboxylic acid, an efficient chiral organocatalyst for direct aldol reactions
Gu, Qing,Wang, Xiao-Fei,Wang, Lei,Wu, Xin-Yan,Zhou, Qi-Lin
, p. 1537 - 1540 (2007/10/03)
Enantioselective aldol reaction of ketones with aldehydes catalyzed by (2S,5S)-pyrrolidine-2,5-dicarboxylic acid in the presence of an equal molar amount of Et3N was described. By using the new chiral organocatalyst, the direct aldol condensati
Asymmetric aldol reaction using immobilized proline on mesoporous support
Calderon, Felix,Fernandez, Raquel,Sanchez, Felix,Fernandez-Mayoralas, Alfonso
, p. 1395 - 1403 (2007/10/03)
The aldol reaction of hydroxyacetone with different aldehydes using immobilized proline on a mesoporous support, assisted by heat and microwaves, has been explored. It was found that heterogenized L-proline on MCM-41 catalyzed aldol reactions in both hydr
