34995-01-2Relevant articles and documents
Solid-phase synthesis of polyfunctional polylysine dendrons using aldehyde linkers
Svenssen, Daniel K.,Mirsharghi, Sahar,Boas, Ulrik
, p. 3942 - 3945 (2014)
A straightforward method for the solid-phase synthesis of C-terminally modified polylysine dendrons has been developed by applying bisalkoxybenzaldehyde and trisalkoxybenzaldehyde linkers. The method has been used for the synthesis of polylysine dendrons with a variety of C-terminal 'tail groups' such as alkyl, propargyl, and dansyl to give dendrons in high crude purity. Furthermore, the method was successful for the synthesis of dendrons with multiple N-terminal pentapeptide groups together with C-terminal alkyl and propargyl tail groups. Finally, the method was shown to be well-suited for automated synthesis.
Fluorescent probes for adenosine receptors: Synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives
Macchia, Marco,Salvetti, Francesca,Barontini, Silvia,Calvani, Federico,Gesi, Marco,Hamdan, Mahmoud,Lucacchini, Antonio,Pellegrini, Antonio,Soldani, Paola,Martini, Claudia
, p. 3223 - 3228 (1998)
New fluorescent ligands for adenosine receptors are described; these compounds were obtained by the insertion, in the N6 position of NECA (a potent adenosine agonist), of dansylaminoalkyl moieties with alkyl spacers of increasing carbon chain length (from 3 to 12). Among them, the compound with a C6 alkyl spacer proved to be the most interesting one, showing a marked selectivity for the A1 receptor subtype; furthermore, in fluorescence microscopy assays it proved to be able to visualize and localize this receptor subtype at the level of the molecular layer of the rat cerebellar cortex.
1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines
Froehlich, Richard F. G.,Furneaux, Richard H.,Mahuran, Don J.,Rigat, Brigitte A.,Stuetz, Arnold E.,Tropak, Michael B.,Wicki, Jacqueline,Withers, Stephen G.,Wrodnigg, Tanja M.
experimental part, p. 1371 - 1376 (2010/10/02)
Cyclization by double reductive amination of D-xylo-hexos-5-ulose with methyl 6-aminohexanoate gave (methoxycarbonyl)pentyl-1-deoxynojirimycin. Reaction of the terminal carboxylic acid with N-dansyl- 1,6-diaminohexane provided the corresponding chain-extended fluorescent derivative. By reaction with bis(6-dansylaminohexyl)amine, the corresponding branched di-N-dansyl compound was obtained. Both compounds are strong inhibitors of D-glucosidases and could also be shown to distinctly improve, at subinhibitory concentrations, the activity of β-glucocerebrosidase in a Gaucher fibroblast (N370S) cell-line through chaperoning of the enzyme to the lysosome.
