350-22-1

Usage

Uses

Used in Pharmaceutical Industry:
AKOS B018293 is used as a building block for the synthesis of pharmaceutical compounds due to its unique chemical structure and properties.
Used in Antineoplastic Applications:
AKOS B018293 is used as a potential antineoplastic agent, indicating its potential to inhibit the growth and proliferation of cancer cells.
Used in Antiviral Applications:
AKOS B018293 is used as a potential antiviral agent, suggesting its ability to inhibit the replication and spread of viruses.
Used in Cyclin-Dependent Kinase Inhibition:
AKOS B018293 is used for its ability to inhibit cyclin-dependent kinases, which play a crucial role in cell cycle regulation and have been implicated in various diseases, including cancer.

InChI:InChI=1/C10H6FNOS2/c11-7-4-2-1-3-6(7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)/b8-5+

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 1236049-23-2 N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-(2-fluorophenylmethylene)-2-thioxo-4-thiazolidinone 
• 1390675-49-6 C₁₁H₈FNOS₂ 
• 1390675-38-3 (Z)-2-(5-(2-fluorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-phenyl-N-tosylpropanamide 
• 1390675-37-2 (Z)-2-(5-(2-fluorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-4-methyl-N-tosylpentanamide 
• 1390675-55-4 C₁₉H₁₅FN₂O₃S 
• 1390675-54-3 C₁₆H₁₇FN₂O₃S 

Relevant academic research and scientific papers

Three substituted (Z)-5-benzylidene-2-thioxothiazolidin-4-ones: Hydrogen-bonded dimers that can be effectively isolated or linked into chains either by aromatic π-π stacking interactions or by dipolar carbonyl-carbonyl interactions

In each of the isomeric compounds (Z)-5-(2-fluorobenzyl-idene)-2- thioxothiazolidin-4-one, C10H6FNOS2, (I), and (Z)-5-(4-fluorobenzylidene)-2-thioxothiazolidin-4-one, C10H 6FN-OS2, (II), th

Combination of 4-anilinoquinazoline and rhodanine as novel epidermal growth factor receptor tyrosine kinase inhibitors

Abstract A type of novel rhodanine-based 4-anilinoquinazoline, which designed the combination between quinazoline as the backbone and various substituted biological rhodanine groups as the side chain, have been synthesized, and their antiproliferative act

Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein

A series of novel rhodanine-based acylsulfonamide derivatives were designed, synthesized, and evaluated as small-molecule inhibitors of anti-apoptotic Bcl-2 protein. These compounds exhibit potent antiproliferative activity in three human tumor cell lines

(Z)-5-[(5-Methyl-1H-imidazol-4-yl)methyl-idene]-2-sulfanyl-idene-1, 3-thia-zolidin-4-one monohydrate: A three-dimensional hydrogen-bonded framework structure

The non-H atoms in the organic component of the title compound, C8H7N3OS2·H2O, are almost coplanar, as the dihedral angle between the two ring planes is only 1.8 (2)°; there is a wide C - C - C angle of 127.8 (3)° at the methine C atom linking the two rin

Synthesis and characterization of (Z)-5-arylmethylidenerhodanines with photosynthesis-inhibiting properties

A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented. Lipophilicity of all the discussed rhodanine derivatives was analyzed using the RP-HPLC method. The compo

Synthesis and antimicrobial activity of some new N-glycosides of 2-thioxo-4-thiazolidinone derivatives

5-Arylidene-2-thioxo-4-thiazolidinones 3a-f react with each of 2,3,4,6-tetra-O-acetyl-α-d-glucopyranosyl and α-d-galactopyranosyl bromides 4a,b in acetone in the presence of aqueous potassium hydroxide at room temperature to afford N-(2,3,4,6-tetra-O-acet

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2

The identification, synthesis and evaluation of a series of rhodanine and thiazolidin-2,4-dione derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 is described. The most potent inhibitors

Synthesis and antifungal activity of (Z)-5-arylidenerhodanines

An efficient microwave-assisted synthesis of new (Z)-5-arylidenerhodanines under solvent-free conditions is described and their in vitro antifungal activity was evaluated following the CLSI (formerly NCCLS) guidelines against a panel of both standardized