350011-89-1Relevant academic research and scientific papers
Biosynthesis of ZrO2 for ZrO2@Ag-S-CH2COOH as the retrievable catalyst for the one-pot green synthesis of pyrazoline derivatives and their anticancer evaluation
Gurav, Rutikesh Pandit,Nalawade, Rohit Dattatray,Sawant, Shivaji Dnyandeo,Satyanarayan, Nayak Devappa,Sankpal, Sandeep Ashok,Hangirgekar, Shankar Poshatti
, (2022/04/03)
In the present work, Ficus benghalensis leaf extract was used for the synthesis of ZrO2 nanoparticles. Further, ZrO2@Ag-S-CH2-COOH was synthesized using biosynthesized ZrO2, and its catalytic potential was examined in the synthesis of pyrazoline from reaction of chalcone and hydrazine hydrate at room temperature. The structural conformation of ZrO2@Ag-S-CH2-COOH has been done using FT-IR, SEM, EDX, XRD, TGA-TDA, XPS, and DLS techniques, high turnover number (TON), and high turnover frequency. The ZrO2@Ag-S-CH2-COOH demonstrated outstanding catalytic activity for the synthesis of pyrazolines. The structures of the pyrazoline derivatives were confirmed by FT-IR, 1H and 13C NMR, and mass spectrometry techniques. Synthesized pyrazoline were tested for anticancer activity against human lung cancer cell line A549 study and confirmed by molecular docking investigations.
Synthesis, antitubercular activity, and QSAR analysis of substituted nitroaryl analogs: Chalcone, pyrazole, isoxazole, and pyrimidines
Gupta, Revathi A.,Kaskhedikar, Satish G.
, p. 3863 - 3880 (2013/07/26)
In the present investigation, 4-nitroacetophenone, on condensation with appropriate aldehydes in ethanolic sodium hydroxide solution, yielded the corresponding chalcones. These corresponding chalcones were reacted with hydrazine hydrate, urea, thiourea, a
Synthesis and antimicrobial activity of some pyrazoline derivatives
Ahirwar,Gautam,Shrivastava
experimental part, p. 5297 - 5302 (2012/07/28)
The objective of present study is to synthesize and screening of antimicrobial activity of some derivatives of pyrazoline. 1H-[4-nitro phenyl-5-(substituted phenyl)]pyrazoline has been used as a precursor to synthesize some biologically active heterocycles. Reaction of 1-(4-nitrophenyl)-3-(substituted phenyl) prop-2-en-1-one with hydrazine hydrate gave 1H-(3-nitrophenyl-5-(substituted phenyl) pyrazoline which on reaction with benzoyl chloride in pyridine gave 1-benzoyl-(4-nitrophenyl)-5-(substituted phenyl) prazoline and on reaction with acetic acid yields 1-acetyl-(4- nitrophenyl)-5-(substituted phenyl) pyrazoline derivatives. Several derivatives have been synthesized and screened for their antimicrobial efficacy against Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae. Antifungal activity against, Aspergillus flavus, Fusarium oxisporum, Aspergillus niger and Trichoderma viridae.
