35002-01-8Relevant academic research and scientific papers
Tf2O-mediated Reaction of Alkenyl Sulfoxides with Unprotected Anilines in Flow Microreactors
Baralle, Alexandre,Inukai, Tomoaki,Nagaki, Aiichiro,Nogi, Keisuke,Osuka, Atsuhiro,Yanagi, Tomoyuki,Yorimitsu, Hideki,Yoshida, Jun-Ichi
, p. 160 - 163 (2020)
Flow microreactors have allowed an efficient extended Pummerer reaction of ketene dithioacetal monoxides with anilines by precise control of unstable sulfonium intermediates and spatial separation of the generation of the intermediates and the nucleophilic attack to the intermediates. A new iodoniummediated cyclization has been devised to convert the products, thioimidates, into indoles.
