35010-29-8

Usage

Appearance

Pale yellow solid

Usage

Synthesis of pharmaceuticals and agrochemicals

Derivation

Derived from benzene

Chemical groups

Contains two fluorine atoms, one nitro group, and one trifluoromethyl group

Reactivity

Highly reactive and volatile

Safety

Should be handled with care due to potential hazards

Importance

Unique chemical structure makes it a valuable building block for the production of various organic compounds

Application

Commonly used in organic synthesis and research

Upstream product

• 400-70-4 2,4-dichloro-5-nitrobenzotrifluoride 
• 320-60-5 2,4-dichloro-benzotrifluoride 
• 1583-58-0 2,4-difluoro-benzoic acid 

Relevant academic research and scientific papers

N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology

Among the ionotropic glutamate receptors, the physiological role of kainate receptors is less well understood. Although ligands with selectivity toward the kainate receptor subtype GluK1 are available, tool compounds with selectivity at the remaining kain

Synthesis and QSAR of Herbicidal 3-Pyrazolyl α,α,α-Trifluorotolyl Ethers

Pyrazole nitrophenyl ethers (PPEs) were recently identified as a novel class of chemistry exerting herbicidal effects by inhibition of protoporphyrinogen IX oxidase. This area of chemistry has been extended to include herbicidal pyrazolyl fluorotolyl ethe

[1,2,4]triazolo[4,3-a]quinoxaline compounds

The present invention relates to [1,2,4]triazolo[4,3-a quinoxaline derivatives of formula I STR1 wherein one of R 1 and R 2 is a 5- or 6-membered nitrogen-containing heterocyclic ring which is optionally substituted with one, two or three substituents, wherein each substituent is independently phenyl or C 1-6 -alkyl, or one of R 1 and R 2 is a fused ring system comprising a 5- or 6-membered nitrogen-containing heterocyclic ring and a benzene, pyridine, pyrimidine or pyrazine ring, wherein the fused ring system is optionally substituted with phenyl or C 1-6 -alkyl; and the other of R 1 and R 2 is hydrogen, C 1-6 -alkyl, C 1-6 -alkoxy, halogen, NO 2, NH 2, CN, CF 3, COC 1-6 -alkyl or SO 2 NR''R"", wherein R'' and R"" are independently hydrogen or C 1-6 -alkyl; and X is O or S; and pharmaceutically acceptable salts thereof. The compounds have affinity for the AMPA receptors and are antagonists in connection with this type of receptors which makes them useful in the treatment of CNS ailments, especially in the treatment of any of the numerous indications caused by hyperactivity of excitatory amino acids.