35019-69-3Relevant academic research and scientific papers
Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis
Juárez-Hernández, Raúl E.,Franzblau, Scott G.,Miller, Marvin J.
, p. 7584 - 7593 (2012/10/29)
Three analogs of mycobactin T, the siderophore secreted by Mycobacterium tuberculosis (Mtb) were synthesized and screened for their antibiotic activity against Mtb H37Rv and a broad panel of Gram-positive and Gram-negative bacteria. The synthetic mycobactins were potent (MIC90 0.02-0.88 μM in 7H12 media) and selective Mtb inhibitors, with no inhibitory activity observed against any other of the microorganisms tested. The maleimide-containing analog 40 represents a versatile platform for the development of mycobactin-drug conjugates, as well as other applications.
