350245-17-9

Upstream product

• 930-21-2 2-azetidinone 
• 68856-96-2 N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine 

Downstream Products

• 162473-78-1 desepoxyarenastatin A 
• 162600-54-6 cryptophycin-24 
• 162600-54-6 arenastatin A 
• 311342-01-5 dephenyldesepoxyarenastatin A 
• 350245-08-8 (1S,3E)-4-N-((1R)-1-((4-methoxybenzyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)carbamoyl)-1-((1R)-1-methyl-2-propenyl)but-3-enyl (2S)-2-hydroxy-4-methylpentanoate 
• 350245-13-5 (1S,3E)-4-N-((1R)-1-((4-methoxybenzyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)carbamoyl)-1-((1R)-1-methyl-2-propenyl)but-3-enyl 4-methyl-2-[(tert-butyldimethylsilyl)oxy]pentanoate 
• 162600-54-6 cryptophycin-24 

Relevant academic research and scientific papers

Synthesis of Cryptophycins via an N-Acyl-β-lactam Macrolactonization

An efficient and concise approach to the synthesis of the macrolide core of the cryptophycins has been developed. A novel macrolactonization utilizing a reactive acyl-β-lactam intermediate incorporates the β-amino acid moiety within the 16-membered macrol

Rapid entry into the cryptophycin core via an acyl-beta-lactam macrolactonization: total synthesis of cryptophycin-24.

[see structure]. An efficient, concise approach to the macrolide core of the cryptophycins, potent antimitotic agents, has been achieved. The reaction sequence features a novel macrolactonization utilizing a reactive acyl-beta-lactam intermediate that inc