35034-15-2

Basic information

• Product Name: 2-Pyrimidinamine, 1-oxide (9CI)
• Synonyms: 2-Pyrimidinamine, 1-oxide (9CI);2-Aminopyrimidine 1-oxide;2-aminopyrimidine N-oxide
• CAS NO: 35034-15-2
• Molecular Formula: C₄H₅N₃O
• Molecular Weight: 111.102
• Product Categories: PYRIMIDINE
• Mol File: 35034-15-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 221°Cat760mmHg
• Flash Point: 87.5°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 0.0227mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 2-Pyrimidinamine, 1-oxide (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 1-oxide (9CI)(35034-15-2)
• EPA Substance Registry System: 2-Pyrimidinamine, 1-oxide (9CI)(35034-15-2)

Safety Data

• Hazardous Substances Data: 35034-15-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H5N3O/c5-4-6-2-1-3-7(4)8/h1-3,5,8H/b5-4+

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 109-12-6 2-aminopyrimidine 

Downstream Products

• 80830-63-3 N,N'-Bis-(1-oxy-pyrimidin-2-yl)-C-phenyl-methanediamine 
• 90998-01-9 5-hydroxy-2-pyrimidinediazotic acid 
• 7752-82-1 5-bromo-2-aminopyrimidine 
• 84539-23-1 5-bromo-2-aminopyrimidine 1-oxide 
• 109-12-6 2-aminopyrimidine 
• 5428-89-7 5-chloropyrimidin-2-amine 
• 88089-61-6 5-chloro-2-aminopyrimidine 1-oxide 
• 102361-84-2 2-(2,4-dimethoxyphenyl)-3-hydroxyimidazo<1,2-a>pyrimidine 
• 123488-66-4 2-(4-Chloro-phenyl)-imidazo[1,2-a]pyrimidin-3-ol 

Relevant articles and documents

AN IMPROVED PROCEDURE FOR THE PREPARATION OF AROMATIC HETEROCYCLIC N-OXIDES

An improved procedure for the preparation of aromatic heterocyclic N-oxide is described.Nitrogen containing heterocyclic compounds gave their N-oxides in excellent yields by the reaction of m-CPBA in DMF/MeOH in the presence of HF in a short time under mild reaction conditions.The presence of HF and MeOH is crucial for the reaction.

Synthesis of some pyrimidine N-oxides

Various monosubstitudes pyrimidines and methylpyrimidines were N-oxidized with a number of different peracids.In general, they are more susceptible to side reactions accompanying N-oxidation (i.e., decomposition, annular carbon oxidation, ring opening) than other ?-deficient diazine and triazine analogs.Unsymmetrical pyrimidines, which can potentially yield two isomeric products, were N-oxidized preferentially at the site para to strong electron-donating substituents.Weaker ringactivating groups, such as methyl, are mainly ortho directing and only aid in the N-oxidation of pyrimidine nuclei having ortho/para-directing substituents.