35042-21-8

Basic information

• Product Name: tetraMethyl pyrazine-2,3,5,6-tetracarboxylate
• Synonyms: tetraMethyl pyrazine-2,3,5,6-tetracarboxylate;Pyrazine-2,3,5,6-tetracarboxylic acid tetraMethyl ester
• CAS NO: 35042-21-8
• Molecular Formula: C12H12N2O8
• Molecular Weight: 312.23228
• EINECS: -0
• Mol File: 35042-21-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 181-182 °C(Solv: methanol (67-56-1); benzene (71-43-2))
• Boiling Point: 393.7°C at 760 mmHg
• Flash Point: 191.9°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 2.08E-06mmHg at 25°C
• Refractive Index: 1.523
• PKA: -7.03±0.10(Predicted)
• CAS DataBase Reference: tetraMethyl pyrazine-2,3,5,6-tetracarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tetraMethyl pyrazine-2,3,5,6-tetracarboxylate(35042-21-8)
• EPA Substance Registry System: tetraMethyl pyrazine-2,3,5,6-tetracarboxylate(35042-21-8)

Safety Data

• Hazardous Substances Data: 35042-21-8(Hazardous Substances Data)

Usage

General Description

Tetramethyl pyrazine-2,3,5,6-tetracarboxylate is a chemical compound that is used primarily as a flavoring agent in food and beverages. It has a strong, nutty and earthy odor and is often added to products to enhance their aroma or taste. tetraMethyl pyrazine-2,3,5,6-tetracarboxylate is also commonly found in nature, as it is a key component of the fragrance of certain fruits and flowers. In addition to its use in the food industry, tetramethyl pyrazine-2,3,5,6-tetracarboxylate also has potential applications in the pharmaceutical and cosmetic industries due to its desirable sensory properties. However, it is important to handle this compound with care, as it may cause irritation or allergic reactions in some individuals.

InChI:InChI=1/C12H12N2O8/c1-19-9(15)5-6(10(16)20-2)14-8(12(18)22-4)7(13-5)11(17)21-3/h1-4H3

Upstream product

• 67-56-1 methanol 
• 43193-60-8 pyrazine-2,3,5,6-tetracarboxylic acid 
• 221171-82-0 dimethyl 2-azido-3-bromobut-2-enedioate 
• 64995-84-2 dimethyl 2-oxo-3-triphenylphosphoranylidenebutanedioate 
• 221171-89-7 dimethyl 2-bromo-2H-azirine-2,3-dicarboxylate 

Relevant articles and documents

Hydrophilic and hydrophobic carboxamide pincers as anion hosts

Hydrophobic and hydrophilic, monotopic and ditopic carboxamide pincer hosts containing ethyl, hexyl, 2-hydroxyethyl and 2-hydroxyethyl ethyl ether pendant arms were synthesized. Solubility trends indicated that solubilities in water or hydrocarbon solvent

Reactivity of 2-halo-2H-azirines. Part II. Thermal ring expansion reactions: Synthesis of 4-haloisoxazoles

The thermolysis of haloazidoalkenes and 2-halo-2H-azirines is described. 2-Benzoyl-2-halo-2H-azirine-3-carboxylates (2a and 2b) underwent ring expansion leading to the synthesis of new 4-haloisoxazoles in high yield. The same isoxazoles were also obtained in high yield directly from haloazidoalkenes (1a and 1b). The thermolysis of the β-azido-α,β-unsaturated ketone 1e led to complete conversion to form the corresponding isoxazole 4e. An isoxazole derivative 4c could also be obtained, in moderate yield, from 2-bromo-3-phenyl-2H-azirine-2-carboxylate (1c). From the thermolysis of azidoalkene 1d the only product that could be isolated was pyrazine-2,3,5,6-tetracarboxylate (5).