3506-73-8

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(3-chlorophenyl)butan-2-one is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its ability to participate in reactions such as acylation and reduction makes it a valuable component in the production of a wide range of medications and other chemical products.
Used in Illicit Drug Production:
Unfortunately, 4-(3-chlorophenyl)butan-2-one is also used in the illicit manufacture of drugs such as amphetamines and methamphetamines. Due to its potential for illegal drug production, it is considered a controlled substance in many countries.
Used in Chemical Research:
In the field of chemical research, 4-(3-chlorophenyl)butan-2-one serves as a subject for study, allowing scientists to explore its properties, reactivity, and potential applications in various chemical reactions and processes.
Safety and Handling:
Given its toxicity, 4-(3-chlorophenyl)butan-2-one should be handled and stored with care in a controlled laboratory environment. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, are essential to minimize risks associated with its use.

Upstream product

• 766-80-3 1-bromomethyl-3-chlorobenzene 
• 123-54-6 acetylacetone 
• 20766-36-3 (E)-4-(3-chlorophenyl)but-3-en-2-one 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 30626-02-9 4-(3-chlorophenyl)but-3-en-2-one 
• 587-04-2 m-Chlorobenzaldehyde 
• 201230-82-2 carbon monoxide 
• 63503-60-6 3-chlorophenylboronic acid 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 1226906-69-9 4-(3-chlorophenyl)butan-2-ol 
• 1443545-64-9 acetic acid (E)-2-acetoxy-5-[5-(3-chlorophenyl)-3-oxo-pent-1-enyl]phenyl ester 
• 1443545-70-7 (E)-5-(3-chlorophenyl)-1-(3,4-dihydroxyphenyl)-pent-1-en-3-one 
• 20766-36-3 (E)-4-(3-chlorophenyl)but-3-en-2-one 

Relevant academic research and scientific papers

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.

D-AMINO ACID OXIDASE INHIBITORS AND THERAPEUTIC USES THEREOF

The present invention relates to compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: each of A, B, C, D, and E, independently, is C, N, N—H, O, S, or absent is a single bond or a double bond; each of X, Y, and Z, independentl

Switchable asymmetric bio-epoxidation of α,β-unsaturated ketones

Efficient asymmetric bio-epoxidation of electron-deficient α,β-unsaturated ketones was realized via a tandem reduction-epoxidation-dehydrogenation cascade, which proceeds in a switchable manner to afford either chiral epoxy ketones or allylic epoxy alcoho

Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation

E-3,4-Dihydroxy styryl aralkyl ketones as well as their 3,4-diacetylated derivatives as the analogues of neuroprotective agent CAPE were designed and synthesized for improving stability and lipid solubility. The neuroprotective activities of target compounds 10a-g and 11a-g were tested by three models in vitro, including 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity, neuronal protecting effect against damage induced by H2O2 in PC12 cells and nitric oxide suppression effect in BV2 microglial cells. The results demonstrated that compounds 10f and 11f exhibited the most potent neuroprotective effect against oxidative stress and inflammation, which is higher than that of the lead compound CAPE.

Chemoselective conjugate reduction of α,β-unsaturated ketones catalyzed by rhodium amido complexes in aqueous media

Although a notable feature of Noyori's Ru-TsDPEN complex is that the transfer hydrogenation reaction is highly chemoselective for the C-O functional group and tolerant of alkenes, our early report indicated that the chemoselectivity could be switched from C-O to C-C bonds in the transfer hydrogenation of activated α,β-unsaturated ketones. Now we have found that a variety of α,β-unsaturated ketones, even without other electron-withdrawing functional groups, could be reduced on the alkenic double bonds with high selectivities employing amido-rhodium hydride complex in aqueous media, and up to 100% chemoselectivity has been achieved. It is notable that the chemoselectivity was improved significantly on going from organic solvent to water. Moreover, a 1,4-addition mechanism has been proposed on the basis of the corresponding experimental details and computational analysis.

New synthesis of 1,4-diketones via rhodium-catalysed 1,4 carbonylative addition of arylboronic acids to α,β-unsaturated ketones

The reaction of various arylboronic acids with α,β-unsaturated ketones under CO pressure and in the presence of rhodium catalyst yields 1,4-diketones.

Substituted guanidine derivatives and process for producing the same

A compound represented by the general formula (1): wherein each of R1, R2, R3, R4and R5is a hydrogen atom, an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a saturated heterocyclic group, an aromatic group, an acyl group or the like; each of Y1, Y2, Y3and Y4is a single bond, —CH2—, —O—, —CO— or the like, provided that at least two of Y1through Y4are independently a group other than a single bond; and Z may be absent, or one or more Zs may be present and are independently an alkyl group, a substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a saturated heterocyclic group, a halogen atom, a carboxyl group, an alkoxycarbonyl group, an aromatic group, an acyl group or the like, is useful as a therapeutic or prophylactic agent for diseases caused by the acceleration of the sodium/proton exchange transport system.