350681-11-7

Basic information

• Product Name: Acetamide, 2-[(diphenylmethylene)amino]-N-[(1S)-1-phenylethyl]-
• CAS NO: 350681-11-7
• Molecular Formula: C23H22N2O
• Molecular Weight: 342.44
• Mol File: 350681-11-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-[(diphenylmethylene)amino]-N-[(1S)-1-phenylethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-[(diphenylmethylene)amino]-N-[(1S)-1-phenylethyl]-(350681-11-7)
• EPA Substance Registry System: Acetamide, 2-[(diphenylmethylene)amino]-N-[(1S)-1-phenylethyl]-(350681-11-7)

Safety Data

• Hazardous Substances Data: 350681-11-7(Hazardous Substances Data)

Upstream product

• 1013-88-3 Benzophenone imine 
• 153645-33-1 N-Phenylethyl hydroxyacetamide 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 36293-01-3 2-chloro-N-((1S)-1-phenylethyl)acetamide 

Relevant articles and documents

Alkylation of N′-[(S)-1′-phenylethyl]-N-(diphenylmethylene)glycinamide using a phase transfer catalyst (PTC) for practical asymmetric syntheses of α-amino acid derivatives

The chiral auxiliary mediated stereoselective alkylation reaction of N′-[(S)-1′-phenylethyl]-N-(diphenylmethylene)glycinamide (1) using a phase transfer catalyst (PTC) is described. Alkylation of 1 using 18-crown-6 as a PTC for liquid-solid extraction of KOH in toluene gives best results. This methodology provides a practical protocol for the preparation of a variety of enantio-enriched unnatural α-amino acid derivatives up to 83:17 enantiomeric ratio.