350683-61-3

Basic information

• Product Name: 2-(5-cyclohexyl-1H-indol-3-yl)-ethanol
• CAS NO: 350683-61-3
• Molecular Weight: 243.349
• Mol File: 350683-61-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-cyclohexyl-1H-indol-3-yl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-cyclohexyl-1H-indol-3-yl)-ethanol(350683-61-3)
• EPA Substance Registry System: 2-(5-cyclohexyl-1H-indol-3-yl)-ethanol(350683-61-3)

Safety Data

• Hazardous Substances Data: 350683-61-3(Hazardous Substances Data)

Upstream product

• 1191-99-7 2,3-dihydro-2H-furan 
• 126062-51-9 4-cyclohexylphenylhydrazine hydrochloride 

Downstream Products

• 1027555-29-8 5-cyclohexyl-3-(2-hydroxy-ethyl)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

A novel series of thromboxane A2 synthetase inhibitors with free radical scavenging and anti-peroxidative activities

A novel series of indoline derivatives with imidazole and carboxyl moieties were synthesized and evaluated for their thromboxane A2 (TXA2) synthetase inhibiting, radical scavenging and anti-peroxidative activities. Among the compounds synthesized, 3.{5-substituted-3-[2-(imidazol-1-yl)ethyl]indolin-1-yl}propionic acids showed free radical scavenging activity and inhibitory effects on lipid-peroxidation of rat brain homogenate and on arachidonate-induced TXA2-dependent aggregation of rabbit platelets. The anti-platelet and anti-peroxidative activities were related to the lipophilicity of the 5-substituent. The 5-hexyloxy derivative (13) showed about 35-fold higher inhibitory activity on TXA2 synthesis than that of ozagrel and about 100-fold higher activity on lipid peroxidation than that of α-tocopherol. Compound 13 showed in vivo anti-thrombotic effect in mice and ex vivo anti-peroxidative activity in rats.