3507-35-5

Upstream product

• 583-68-6 2-bromo-p-toluidine 
• 140-89-6 potassium ethyl xanthogenate 
• 74-88-4 methyl iodide 
• 3507-26-4 2-chloro-6-methylbenzo[d]thiazole 
• 2268-79-3 2-mercapto-6-methylbenzothiazole 
• 77-78-1 dimethyl sulfate 
• 2268-79-3 6-methyl-1,3-benzothiazole-2(3H)-thione 

Downstream Products

• 615-22-5 2-methylmercaptobenzothiazole 
• 864263-96-7 2-cyclohexyl-6-methylbenzo[d]thiazole 

Relevant academic research and scientific papers

Palladium-Catalyzed Insertion of Isocyanides into the C?S Bonds of Heteroaryl Sulfides

Insertion of tert-butyl isocyanide into the C(sp2)?S bonds of heteroaryl sulfides is catalyzed by a palladium diphosphine complex. Thioimidates generated through this reaction could be readily hydrolyzed under acidic conditions to yield the corresponding thioesters, which are of synthetic use. This insertion is useful because starting heteroaryl sulfides were readily prepared by either conventional ways or through sulfur-specific extended Pummerer reactions.

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70)

Cancer cells rely on the chaperone heat shock protein 70 (Hsp70) for survival and proliferation. Recently, benzothiazole rhodacyanines have been shown to bind an allosteric site on Hsp70, interrupting its binding to nucleotide-exchange factors (NEFs) and promoting cell death in breast cancer cell lines. However, proof-of-concept molecules, such as JG-98, have relatively modest potency (EC50 ≈ 0.7-0.4 μM) and are rapidly metabolized in animals. Here, we explored this chemical series through structure- and property-based design of ～300 analogs, showing that the most potent had >10-fold improved EC50 values (～0.05 to 0.03 μM) against two breast cancer cells. Biomarkers and whole genome CRISPRi screens confirmed members of the Hsp70 family as cellular targets. On the basis of these results, JG-231 was found to reduce tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip). Together, these studies support the hypothesis that Hsp70 may be a promising target for anticancer therapeutics.