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(+/-)-cis-tetrahydro-furo[3,4-c]furan-1,4-dione is a complex organic compound with a unique chemical structure. It belongs to the class of furan derivatives, which are heterocyclic compounds containing a furan ring. The compound is characterized by a cis-configuration, indicating that the two functional groups (1,4-dione) are on the same side of the tetrahydrofuran ring. This specific arrangement of atoms and functional groups gives rise to distinct chemical properties and potential applications in various fields, such as pharmaceuticals, agrochemicals, or materials science. The compound's structure and properties make it an interesting target for synthetic chemists and researchers in the field of organic chemistry.

3508-52-9

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3508-52-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3508-52-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,0 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3508-52:
(6*3)+(5*5)+(4*0)+(3*8)+(2*5)+(1*2)=79
79 % 10 = 9
So 3508-52-9 is a valid CAS Registry Number.

3508-52-9Downstream Products

3508-52-9Relevant academic research and scientific papers

Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases

Peng, Hairuo,Kim, Doeg-Il,Sarkaria, Jann N,Cho, Yong-Seo,Abraham, Robert T,Zalkow, Leon H

, p. 167 - 174 (2002)

Several pyrrolo-quinoline γ-lactones were found as novel inhibitors for two members of the PI3-kinase related kinase (PIKK) family. Ataxia-Telangiectasia-mutated (ATM) protein and the mammalian Target of Rapamycin (mTOR). Preliminary structure-activity relationship studies indicated that an electrophilic exocyclic double bond conjugated to the carbonyl group of the γ-lactone ring was crucial for the PIKK inhibitory potency. One of the best ATM inhibitors in this series, DK8G557, showed IC50 values of 0.6 and 7.0 μM for ATM and mTOR, respectively. This compound exhibited potent and selective growth inhibition activities in the NCI 60 human tumor cell line screen with a GI50 MG-MID value of 2.69 μM. The best mTOR inhibitor in this series, HP9912, exhibited IC50 values of 0.5 and 6.5 μM for mTOR and ATM, respectively. These compounds suggest novel leads for the discovery of potent small molecule inibitors of PIKKs as potential anticancer drugs, with therapeutic activities as either single, or as sensitizing agents to conventional radio-, or chemo-therapeutic strategies. Copyright

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