35084-48-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(ADAMANTANE-1-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID is used as a building block for drug development due to its unique structure and properties that may contribute to the creation of effective antiviral and antimicrobial agents. Its adamantane moiety provides stability and rigidity, enhancing the compound's potential in medicinal chemistry.
Used in Medicinal Chemistry Research:
1-(ADAMANTANE-1-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID is utilized as a subject of study for its intriguing structural and chemical properties, which could lead to advancements in the understanding of its therapeutic applications and the development of novel pharmaceuticals.

InChI:InChI=1/C16H23NO3/c18-14(19)13-2-1-3-17(13)15(20)16-7-10-4-11(8-16)6-12(5-10)9-16/h10-13H,1-9H2,(H,18,19)/p-1/t10?,11?,12?,13-,16?/m1/s1

Upstream product

• 2094-72-6 1-Adamantanecarbonyl chloride 
• 147-85-3 L-proline 

Relevant academic research and scientific papers

Compositions and methods for inducing CD81 dependent antiproliferation and for treating hepatitis C and other disorders

Small molecule analogues of 1-aminoadamantane and methods for using such compositions to induce CD81-dependent antiproliferative effects and/or for the treatment of disorders of human or veterinary patients and/or for the manufacture of therapeutic prepar

Synthesis and antiamnesic activity of a series of N-acylprolyl-containing dipeptides

Eaters and amides of a series of N-acylprolyl-containing dipeptides were synthesized. It was established that these substances possess the ability to prevent memory decline evoked by maximal electroshock (MES) in a passive avoidance step-through paradigm. These N-acylprolyl-containing dipeptides were designed as analogues of pyroglutamyl-containing dipeptides, which we previously demonstrated to be highly active nootropics. Among the structure-activity relationships explored were the effect of N-acylsubstitution size, C-terminal substitution and the nature of the second amino acid. The optimal N-acyl moiety was the N-phenyl-acetyl group, while the optimal C-terminal substitution-esters were those derived from low alkyl alcohols. The optimal second amino acids were Asp, Glu or their fragments, Gly, β-Ala, GABA. Compound 1 (N-phenylacetylprolylglycine ethyl eater) was selected for further evalution in impaired cognitive functions. It was supposed that esters and unsubstituted amides of N-acylprolylglycines are prodrugs, which convert to the bioactive cyclo-(Pro-Gly) by virtue of enzymatic or chemical lability within the body.