3509-50-0

Usage

Uses

Used in Pharmaceutical Industry:
(6Z)-6-[(2-hydroxy-1,1-dimethylethyl)amino]methylidenecyclohexa-2,4-dien-1-one is used as a potential pharmacologically active compound for its possible biological activity and the presence of a reactive amino group that could be utilized for drug conjugation or targeting specific biological pathways.
Used in Drug Development:
(6Z)-6-[(2-hydroxy-1,1-dimethylethyl)amino]methylidenecyclohexa-2,4-dien-1-one is used as a starting material for the development of new drugs due to its unique structure and the potential for further chemical modifications to enhance its properties and efficacy.
Used in Research and Development:
(6Z)-6-[(2-hydroxy-1,1-dimethylethyl)amino]methylidenecyclohexa-2,4-dien-1-one is used as a research compound to study its properties, potential interactions with biological systems, and to explore its possible applications in various fields, including medicine and pharmaceuticals.

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 25452-26-0 2-[(2-Hydroxy-1,1-dimethyl-ethylamino)-methyl]-phenol 
• 103257-75-6 VO(SALAMHP) 
• 211056-41-6 MoO₂⁽²⁺⁾*(OC₆H₄CHNC(CH₃)2CH₂O)^(2-)=[MoO₂(OC₆H₄CHNC(CH₃)2CH₂O)] 
• 180091-92-3 VO⁽³⁺⁾*C₁₁H₁₃NO₂^(2-)*C₉H₆NO^(1-) = [VO(C₁₁H₁₃NO₂)(C₉H₆NO)] 
• 203641-72-9 5,5-dimethyl-2-phenylbenzo[h]-6-aza-1,3,2-dioxaboracyclonon-6-ene 
• 203641-73-0 7,7-dimethyl-2,4-diphenylbenzo[j]-8-aza-1,3,5,2,4-trioxadiboracycloundeca-8-ene 
• 3539-94-4 2-((2-hydroxybenzylidene)amino)-2-methylpropyl benzoate 
• 172615-18-8 VO⁽³⁺⁾*OC₆H₄CHNC(CH₃)2CH₂O^(2-)*O₂P(OC₂H₅)2^(1-)=VO(O₂P(OC₂H₅)2)(OC₆H₄CHNC(CH₃)2CH₂O) 
• 172615-17-7 VO(OC₆H₄Cl)(OC₆H₄CHNC(CH₃)2CH₂O) 

Relevant academic research and scientific papers

Palladium-Catalyzed Oxidation of β-C(sp3)-H Bonds of Primary Alkylamines through a Rare Four-Membered Palladacycle Intermediate

Site-selective functionalizations of C-H bonds are often achieved with a directing group that leads to five- or six-membered metallacyclic intermediates. Analogous reactions that occur through four-membered metallacycles are rare. We report a challenging palladium-catalyzed oxidation of primary C-H bonds β to nitrogen in an imine of an aliphatic amine, a process that occurs through a four-membered palladacyclc intermediate. The success of the reaction relies on the identification, by H/D exchange, of a simple directing group (salicylaldehyde) capable of inducing the formation of this small ring. To gain insight into the steps of the catalytic cycle of this unusual oxidation reaction, a series of mechanistic experiments and density functional theory (DFT) calculations were conducted. The experimental studies showed that cleavage of the C-H bond is rate-limiting and formation of the strained four-membered palladacycle is thermodynamically uphill. DFT calculations corroborated these conclusions and suggested that the presence of an intramolecular hydrogen bond between the oxygen of the directing group and hydroxyl group of the ligating acetic acid is crucial for stabilization of the palladacyclic intermediate.

Four-, five- and six-coordinated ZnII complexes of OH-containing ligands: Syntheses, structure and reactivity

Four-, five- and six-coordinated complexes of ZnII with OHrich molecules possessing an ONO binding core were synthesized, characterized and their structures were established by single-crystal X-ray diffraction. The corresponding metal ion geometries were found to be distorted tetrahedral, square pyramidal and octahedral, respectively. The complexes exhibit interesting lattice structures such as layered and corrugated sheets owing to the presence of a number of weak intermolecular interactions. The five-coordinated, water-bound ZnII complex was studied because of its putative hydrolysis property towards p-nitrophenyl acetate. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.