35091-64-6

Basic information

• Product Name: NPROPYLNNITROGUANIDINE
• Synonyms: 1-Nitro-3-propylguanidine
• CAS NO: 35091-64-6
• Molecular Formula: C₄H₁₀N₄O₂
• Molecular Weight: 146.15
• Mol File: 35091-64-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 270.7°Cat760mmHg
• Flash Point: 117.5°C
• Appearance: /
• Density: 1.35g/cm³
• CAS DataBase Reference: NPROPYLNNITROGUANIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: NPROPYLNNITROGUANIDINE(35091-64-6)
• EPA Substance Registry System: NPROPYLNNITROGUANIDINE(35091-64-6)

Safety Data

• Hazardous Substances Data: 35091-64-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H11N4O2/c1-2-3-6-4(5)7-8(9)10/h2-3H2,1H3,(H,9,10)(H3,5,6,7)/q+1

Upstream product

• 107-10-8 propylamine 
• 2986-25-6 S-methyl-N-nitroisothiourea 
• 540-54-5 1-Chloropropane 
• 556-88-7 2-nitroguanidine 
• 106-94-5 propyl bromide 
• 2986-25-6 methyl nitrocarbamimidothioate 
• 556-88-7 nitroguanidine 
• 70-25-7 N-Methyl-N'-nitro-N-nitrosoguanidine 

Downstream Products

• 13010-07-6 N-Propyl-N'-nitro-N-nitrosoguanidine 
• 13010-07-6 N-Nitroso-N'-nitro-N-propyl-guanidin 

Relevant articles and documents

Design, Synthesis, and Antifungal Activity of Sulfoximine Derivatives Containing Nitroguanidine Moieties

To discover novel pesticide candidates, a series of sulfoximine derivatives were designed and synthesized via the oxidation coupling reaction of sulfides and N-alkyl nitroguanidines. The compounds were evaluated for their antifungal activity against six phytopathogenic fungi. Most of them exhibited a broad spectrum of fungicidal activity in vitro. Compound 8IV-b displayed good fungicidal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Phytophthora capsici, with EC50 value of 12.82, 12.50, 17.25, 31.08, and 30.11 mg/L, respectively. In addition, compounds 8III-c and 8IV-e had EC50 values of 22.23 and 20.67 mg/L against P. capsic, which were significantly better than that of the commercial procymidone (118.15 mg/L). Strikingly, 8IV-d exhibited satisfactory fungicidal activity against B. cinerea, which was comparable to control procymidone in terms of their EC50 values (7.42 versus 10.83 mg/L), and the bioassays in vivo further confirmed that 8IV-d possessed potent protective effect against B. cinerea at 200 mg/L (72.2 %). These present findings will facilitate the design and development of novel potent fungicides.

Method for preparing propyl nitroguanidine

The invention discloses a method for preparing propyl nitroguanidine. With nitroguanidine and n-propylamine taken as raw materials, the method comprises the following steps: adding distilled water toa reaction bottle, adding nitroguanidine and n-propylamine sequentially for reaction at a reaction temperature of 30-60 DEG C for 1 h-4 h, adjusting pH of the reaction system by inorganic acid to 1-6,and performing filtration and recrystallization to obtain propyl nitroguanidine, wherein nitroguanidine, n-propylamine and water are in a mass ratio of 1:(0.3-0.6):(5-20), and the recrystallization solvent is an organic solvent. The method aims to solve the problems of multiple reaction steps, various raw materials, high cost, low yield and the like in the preparation process of propyl nitroguanidine, and is mainly used for preparing propyl nitroguanidine.

Mutagenic and prophage-inducing activities of 1-alkyl-3-nitro-1-nitrosoguanidines.

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