70-25-7 Usage
Chemical Properties
yellow to pink crystals
Uses
Different sources of media describe the Uses of 70-25-7 differently. You can refer to the following data:
1. A DNA-damaging agent, used as a positive control in SHE cell transformation assays.
2. Experimentally as carcinogen and mutagen. Formerly in preparation of diazomethane.
Definition
ChEBI: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position
Production Methods
MNNG is one of the first chemical mutagens and is a
stabilized form of methylnitrosoguanidine, which has not
been isolated. It does not occur in nature, and human exposure
to it is limited to laboratories.
General Description
A yellow powder. Melting point 244°F. Decomposes above 212°F. A suspected carcinogen. Extremely hazardous as a mutagen. Avoid skin contact and inhalation of of vapors. Usually stored frozen (below 32°F) in polyethylene bottles that are tightly closed and contained in a metal can. May decomposed during prolonged storage and develop sufficient pressure in a closed container to explode. Keep away from heat, sparks, and open flame.
Air & Water Reactions
Highly flammable. Reacts violently with water .
Reactivity Profile
1-Methyl-3-nitro-1-nitrosoguanidine will detonate under high impact. 1-Methyl-3-nitro-1-nitrosoguanidine is sensitive to heat. A sample has exploded when melted in a sealed capillary tube. Incompatible with acids, bases, oxidizing agents and reducing agents. Reacts with bases to release highly toxic, irritating and explosive gases. Reacts slowly with acids to release nitrous acid. Reacts with various nucleophiles, especially amines and thiols. Reacts with aqueous potassium hydroxide to form a highly reactive compound. The crude product from aqueous nitrosation is pyrophoric but recrystallized material is stable .
Health Hazard
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
tumorigenic, and teratogenic data. Poison by
ingestion, intraperitoneal, and intravenous
routes. Moderately toxic by subcutaneous
route. Experimental reproductive effects.
Human mutation data reported. An
explosive sensitive to heat or impact.
Flammable when exposed to heat or flame;
can react vigorously with oxidizing
materials. When heated to decomposition it
emits very toxic fumes of NOx.
Carcinogenicity
N-Methyl-N-nitro-N-nitrosoguanidine (MNNG) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Check Digit Verification of cas no
The CAS Registry Mumber 70-25-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 70-25:
(4*7)+(3*0)+(2*2)+(1*5)=37
37 % 10 = 7
So 70-25-7 is a valid CAS Registry Number.
70-25-7Relevant articles and documents
Insensitive nitrogen-rich materials incorporating the nitroguanidyl functionality
Zhang, Qinghua,He, Chunlin,Yin, Ping,Shreeve, Jean'Ne M.
, p. 212 - 217 (2014/01/06)
A new class of nitroguanidylfunctionalized nitrogen-rich materials derived from 1,3,5-triazine and 1,2,4,5- tetrazine was synthesized through reactions between N-nitroso-N'-alkylguanidines and the hydrazine derivatives of 1,3,5-triazine or 1,2,4,5-tetrazine. These compounds were fully characterized using multinuclear NMR and IR spectroscopies, elemental analysis, and differential scanning calorimetry (DSC). The heats of formation for all compounds were calculated with Gaussian 03 and then combined with experimental densities to determine the detonation pressures (P) and velocities (D v) of the energetic materials. Interestingly, some of the compounds exhibit an energetic performance (P and Dv) comparable to that of RDX, thus holding promise for application as energetic materials. Copyright