350984-55-3Relevant academic research and scientific papers
Efficient solid-phase synthesis of 4,5-dihydro-1,2,4-triazin-6(1H)-ones
Boeglin, Damien,Cantel, Sonia,Martinez, Jean,Fehrentz, Jean-Alain
, p. 459 - 462 (2003)
A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4,5-dihydrotriazinones were obtained in high purity.
