350994-49-9Relevant academic research and scientific papers
Revisiting the reaction of β-chloroacroleins with 2-aminophenol: a new observation
Bera, Rabin,Dhananjaya,Singh, Shambu Nath,Ramu,Kiran, Sai Uday,Kumar, P. Rajender,Mukkanti,Pal, Manojit
, p. 582 - 589 (2008)
The reaction of β-chloroacrolein with 1 equiv of 2-aminophenol in DMF proceeds smoothly to afford 11-hydroxy derivative of chromenoquinoline in good yield. This single pot method allows for a rapid access to a variety of chromenoquinolines or oxepinoquinolines depending on the nature of β-chloroacrolein used. The structures were established by spectroscopic data and further confirmed by X-ray diffraction analysis. A plausible mechanism for this reaction has been proposed. The reaction seemed to proceed via a chloroimine species, whose intermediacy has been established, followed by the construction of the fused quinoline ring.
Studies on the reactivity of new types of tetracyclic-1,5-benzoxazepines: Part V
Sekhar,Ramana,Ramadas
, p. 383 - 386 (2007/10/03)
The syntheses of tetracyclic 1,5-benzoxazepines 3a-e from heterocyclic β-chloroaldehydes 1a-e and 2-aminophenol are reported herein (Scheme I). Attempted lithium aluminium hydride (LiAlH4) reduction of the imine double bond in 3a-e failed to fu
