350997-68-1Relevant articles and documents
Synthesis and evaluation of antimicrobial and anticancer activities of 3-phenyl-1-phenylsulfonyl pyrazoles containing an aminoguanidine moiety
Huang, Yushan,Hu, Hongmei,Yan, Rui,Lin, Liwen,Song, Mingxia,Yao, Xiaodong
, (2020/10/15)
A series of 3-phenyl-1-phenylsulfonyl pyrazoles containing an aminoguanidine moiety was designed, synthesized, and evaluated for their antimicrobial and anticancer activities. The majority of the target compounds showed broad-spectrum antimicrobial activi
4,5-diazafluorene derivative, preparation method and applications thereof
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Paragraph 0042; 0043; 0045; 0046; 0047; 0048, (2018/11/22)
The invention relates to a 4,5-diazafluorene derivative, a preparation method and applications thereof, wherein a 1,10-phenanthroline monohydrate and potassium permanganate are subjected to an oxidizing reaction to obtain a 4,5-diazafluoren-9-one intermed
2'-pyrazol-1H-imidazole [4,5-f][1,10] phenanthroline derivate and preparing method and application thereof
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Paragraph 0046; 0048, (2017/05/19)
The invention relates to a 2'-pyrazol-1H-imidazole [4,5-f][1,10] phenanthroline derivate and a preparing method and application thereof. According to the 2'-pyrazol-1H-imidazole[4,5-f][1,10] phenanthroline derivate, different substituted acetophenone and semicarbazlde hydrochloride and 2,4-dinitrobenzene serve as raw materials, the target compound, namely the 2'-pyrazol-1H-imidazole [4,5-f][1,10] phenanthroline derivate is obtained through a five-step reaction, and the obtained target compound is used for applied research of cell line growth inhibition and apoptosis activity for resisting three kinds of cancer cells including the non-small cell lung cancer cell lines A549, human liver cancer cell lines HepG2 and human breast carcinoma cell lines MCF-5. Most compounds can make the experiment cancer cells restrained and apoptotic, high effects are generated on the A549 and HepG2 cell lines are achieved particularly, and selective toxicity on the A549 cell lines is generated particularly. According to the 2'-pyrazol-1H-imidazole [4,5-f][1,10] phenanthroline derivate, a large reference value is provided for finding new anti-tumor micromolecular medicines and is particularly provided for promoting clinical medicine research and development of the phenanthroline derivate.