351-18-8Relevant academic research and scientific papers
Microwave-assisted oxidative coupling of amines to imines on solid acid catalysts
Landge, Shainaz M.,Atanassova, Valentina,Thimmaiah, Muralidhara,T?r?k, Béla
, p. 5161 - 5164 (2008/02/10)
A K-10 montmorillonite catalyzed microwave-assisted oxidative coupling of amines is described. Substituted benzylamines readily undergo self-coupling reactions to produce benzylidene-benzylamines, while aliphatic amines and anilines cannot form self-coupl
Phosphatase inhibitors. III. Benzylaminophosphonic acids as potent inhibitors of human prostatic acid phosphatase
Beers, Scott A.,Schwender, Charles F.,Loughney, Deborah A.,Malloy, Elizabeth,Demarest, Keith,Jordan, Jerold
, p. 1693 - 1701 (2007/10/03)
Further investigation of the structural requirements of a series of benzylphosphonic acid inhibitors of human prostatic acid phosphatase has led to the highly potent series of α-aminobenzylphosphonic acids. The α-benzylaminobenzylphosphonic acid, with an IC50 = 4 nM, exhibited a 3500-fold improvement in potency over the carbon analogue, α-phenylethyl. The enhanced potency may be due to a combination of four favorable interactions including those with the phosphate binding region, the presence the hydrophobic moieties of the benzylamino and phenylphosphonic acid, and a rigid conformer produced by an internal salt bridge between the phosphonate and the α-amino group. Replacement of the phosphonic acid moiety with a phosphinic or carboxylic acid as well as deletion of the benzyl substitution on the α-amino group led to great reductions in potency.
SYNTHESE VON FLUORIERTEN N-ARYLAMINO-ARYLMETHANPHOSPHONSAEUREDIALKYLESTERN
Gruss, Ulrike,Haegele, Gerhard
, p. 209 - 222 (2007/10/02)
Fluorinated α-C- and N-arylsubstituted aminomethanephosphonic acid diethylesters 5 are prepared in high yields by a "two-step" procedure: mixing equimolar amounts of fluorinated benzaldehydes 1 and anilines 2 to benzaldehyde-(N-aryl-)imines 3.Subsequently
