351003-15-1

Usage

InChI:InChI=1/C9H9BrOS/c1-7(11)12-6-8-2-4-9(10)5-3-8/h2-5H,6H2,1H3

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 10387-40-3 potassium thioacetate 
• 237763-11-0 methanesulfonic acid 4-bromo-benzyl ester 
• 873-75-6 4-bromobenzenemethanol 
• 507-09-5 tiolacetic acid 

Downstream Products

• 19552-10-4 4-bromobenzyl mercaptan 
• 29673-86-7 -benzyl-disulfid 
• 53531-69-4 (4-bromo-phenyl)-methanesulfonyl chloride 
• 1613303-78-8 N-(3-chlorophenyl)-N-isobutyl-1-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)methanesulfonamide 

Relevant academic research and scientific papers

Design and synthesis of chiral spirobifluorenes

Chiroptical spectroscopic methods serve as a practical tool for the structural characterization of chiral systems based on the interaction with polarized light. The higher sensitivity of these methods, compared with their achiral counterparts, not only enables the determination of absolute configuration and conformational preferences, but also supramolecular interactions may be monitored. In order to expand the applicability of chiroptical systems, the development of functional materials exhibiting intense chiroptical responses is essential. As a proof of principle, we previously constructed chiroptical interfaces via thioacetate-derivatized allenes. Because of the photoisomerization issues associated with allenes, we have recently proposed their replacement by spirobifluorenes to achieve robust chiroptical systems. Thus, we hereby present the design and synthesis of chiral spirobifluorenes bearing thioacetates suitable for suface functionalization.

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

BENZENE SULFONAMIDE DERIVATIVES AND THEIR USE AS RORC MODULATORS

Compounds of the formula la or lb: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, D, E, G, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

BENZYL SULFONAMIDE DERIVATIVES AS RORC MODULATORS

Compounds of the formula Ia or Ib: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS

Compounds of the formula Ia or Ib: or pharmaceutically acceptable salts thereof, wherein m, n, r, A, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6

Convenient synthesis of alkyl thioacetate from alkyl halide using a polymer-supported sodium thioacetate

Alkyl halides are efficiently converted to their corresponding S-alkyl thioacetates under mild and nonaqueous conditions, using polymer-supported sodium thioacetate as a new polymeric reagent at room temperature in high yields and purity. The spent polymeric reagent can be removed quantitatively by filtration and pure products can be obtained by evaporation of the solvent. The spent polymeric reagent can be regenerated and reused several times without its activity changing appreciably. Iranian Chemical Society 2012.

Synthesis of radioiodine labeled dibenzyl disulfide for evaluation of tumor cell uptake

Benzyl 4-halobenzyl and ally benzyl disulfide were synthesized as diallyl disulfide analogues and their tumor growth inhibitory effects on the cancer cells (SNU C5 and MCF-7) were comparable to that of diallyl disulfide, indicating that the disulfide func