35104-84-8Relevant academic research and scientific papers
One-pot green synthesis and bio-assay of pyrazolylphosphonates
Mohan, Gundluru,Santhisudha, Sarva,Murali, Sudileti,Reddy, Nemallapudi Bakthavatchala,Sravya, Gundala,Zyryanov, Grigory V,Reddy, Cirandur Suresh
, p. 3475 - 3491 (2018)
An efficient one-pot synthesis of bioactive pyrazolylphosphonates is accomplished by the reaction of 3-methyl-1-phenyl-2-pyrazoline-5-one with various aryl aldehydes and diethyl phosphite in the presence of β-cyclodextrin (β-CD) as a catalyst. The compounds were tested for their anti-oxidant activity by DPPH and H2O2 radical scavenging assay and for anticancer activity against breast cancer (MCF-7), prostate cancer (DU-145) and lung cancer (A-549) cell lines with sulfarodamine-B (SRB) assay. Most of the synthesized compounds showed promising anti-oxidant activity and significant anticancer activity when compared with the standard drugs.
