351317-23-2

Basic information

• Product Name: 7,10,13,16,19-Docosapentaenamide, N-(2-hydroxyethyl)-, (7Z,10Z,13Z,16Z,19Z)-
• CAS NO: 351317-23-2
• Molecular Formula: C24H39NO2
• Mol File: 351317-23-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7,10,13,16,19-Docosapentaenamide, N-(2-hydroxyethyl)-, (7Z,10Z,13Z,16Z,19Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 7,10,13,16,19-Docosapentaenamide, N-(2-hydroxyethyl)-, (7Z,10Z,13Z,16Z,19Z)-(351317-23-2)
• EPA Substance Registry System: 7,10,13,16,19-Docosapentaenamide, N-(2-hydroxyethyl)-, (7Z,10Z,13Z,16Z,19Z)-(351317-23-2)

Safety Data

• Hazardous Substances Data: 351317-23-2(Hazardous Substances Data)

Upstream product

• 119818-40-5 (7Z,10Z,13Z,16Z,19Z)-ethyl docosa-7,10,13,16,19-pentaenoate 
• 141-43-5 ethanolamine 
• 875288-80-5 methyl (2E,7Z,10Z,13Z,16Z,19Z)-docosa-2,7,10,13,16,19-hexaenoate 
• 2234-74-4 docosa-7Z,10Z,13Z,16Z,19Z-pentaenoic acid 

Relevant articles and documents

Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77

In this work, three series of ω-3 polyunsaturated fatty acid-alkanolamine derivatives (PUFA-AAs) were synthesized, characterized and their anti-inflammatory activity in vivo was evaluated. Compounds 4a, 4f, and 4k exhibited marked anti-inflammatory activity in LPS-stimulated RAW 264.7 cells. The most promising compound 4k dose-dependently suppressed the cytokines with IC50 values in the low micromolar range. Further, 4k exhibited potential in vitro Nur77-binding affinity (Kd = 6.99 × 10?6 M) which is consistent with the result of docking studies. Next, the anti-inflammatory mechanism of 4k was found to be through NF-κB signal pathway in a Nur77-dependent manner. Moreover, we also observed 4k significantly inhibited LPS-induced expression of cytokines (IL-6, TNF-α, and IL-1β) through suppressing NF-κB activation and attenuated LPS-induced inflammation in mouse acute lung injury (ALI) model. In conclusion, the study strongly suggests that the PUFA-AA derivatives can be particularly as new Nur77 mediators for further treatment in inflammatory diseases.

One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties

A one-pot environmentally friendly transamidation of ω-3 fatty acid ethyl esters to amides and mono- or diacylglycerols was investigated via the use of a polymer-supported lipase. The method was used to synthesize a library of fatty acid monoglyceryl esters and amides. These new derivatives were found to have potent growth inhibition effects against A549 lung cancer cells.