351331-57-2

Upstream product

• 351331-49-2 (3R,4R,5S,6S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-2,2,4,6-tetramethyl-octanoic acid ethyl ester 
• 351331-52-7 (3R,4R,5S,6S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-non-8-enoic acid ethyl ester 
• 351331-53-8 (3R,4R,5S,6S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-non-8-enal 
• 297131-88-5 5-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-74-9 (3R,4S,5R)-5-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-77-2 (3R,4R,5S,6S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-octanedioic acid diethyl ester 
• 297131-76-1 (E)-(4S,5R,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-5,7,7-trimethyl-oct-2-enedioic acid diethyl ester 
• 297131-73-8 (E)-(5S,6R)-6-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hept-3-enoic acid methyl ester 
• 297131-75-0 (3R,4R,5R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-89-6 (3R,4R,5R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4-trimethyl-6-oxo-hexanoic acid ethyl ester 
• 297131-87-4 (2R,3R)-3-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyraldehyde 
• 14642-79-6 benzyloxy-trimethylsilane 
• 351331-56-1 (3S,5R,6R,7S,8S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid isopropyl ester 

Relevant academic research and scientific papers

Methodology based on chiral silanes in the synthesis of polypropionate-derived natural products - Total synthesis of epothilone A

Epothilones A and B (1 and 2) are natural products with potent antitumor activity. These compounds have a Taxol-like mechanism of action against tumor cells. A total synthesis of epothilone A (1) is reported, which is based on the synthesis and union of t