351341-22-5Relevant academic research and scientific papers
Nucleoside H-phosphonates. 17. Synthetic and 31P NMR studies on the preparation of dinucleoside H-phosphonothioates
Zain,Stawinski
, p. 6617 - 6622 (1996)
Formation of H-phosphonothioate diesters via condensation of H-phosphonate monoesters with a hydroxylic component in the presence of various coupling agents and possible side reactions that may accompany this process were studied using 31P NMR spectroscopy. Optimal reaction conditions, which eliminate or significantly suppress the side reactions, have been designed and assessed in syntheses of dinucleoside H-phosphonothioate diesters.
