351351-75-2Relevant articles and documents
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents
Martins, Cristina,Gunaratnam, Mekala,Stuart, John,Makwana, Vaidahi,Greciano, Olga,Reszka, Anthony P.,Kelland, Lloyd R.,Neidle, Stephen
, p. 2293 - 2298 (2008/02/02)
The design, synthesis, biophysical and biochemical evaluation is presented of a new series of benzylamino-substituted acridines as G-quadruplex binding telomerase inhibitors. Replacement of the previously reported anilino substituents by benzylamino group