351351-75-2Relevant academic research and scientific papers
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents
Martins, Cristina,Gunaratnam, Mekala,Stuart, John,Makwana, Vaidahi,Greciano, Olga,Reszka, Anthony P.,Kelland, Lloyd R.,Neidle, Stephen
, p. 2293 - 2298 (2008/02/02)
The design, synthesis, biophysical and biochemical evaluation is presented of a new series of benzylamino-substituted acridines as G-quadruplex binding telomerase inhibitors. Replacement of the previously reported anilino substituents by benzylamino group
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors
Harrison, R. John,Cuesta, Javier,Chessari, Gianni,Read, Martin A.,Basra, Sanji K.,Reszka, Anthony P.,Morrell, James,Gowan, Sharon M.,Incles, Christopher M.,Tanious, Farial A.,Wilson, W. David,Kelland, Lloyd R.,Neidle, Stephen
, p. 4463 - 4476 (2007/10/03)
The synthesis and evaluation for telomerase-inhibitory and quadruplex DNA binding properties of three related series of rationally designed trisubstituted acridine derivatives are described. These are substituted on the acridine ring at the 2,6,9; 2,7,9;
