71535-97-2

Usage

InChI:InChI=1/C13H6N4O9/c18-13(9-3-1-7(14(19)20)5-11(9)16(23)24)10-4-2-8(15(21)22)6-12(10)17(25)26/h1-6H

Upstream product

• 1817-76-1 2,2',4,4'-tetranitrodiphenylmethane 
• 64-19-7 acetic acid 
• 101-81-5 Diphenylmethane 

Downstream Products

• 71503-90-7 3,6-dinitro-10-p-tolylacridin-9-one 
• 154010-53-4 2',4,4'-trinitro-2'-p-toluidinobenzophenone 
• 154010-63-6 2-p-chloroanilino-2',4,4'-trinitrobenzophenone 
• 71503-89-4 3,6-dinitro-10-phenylacridin-9-one 
• 71642-37-0 2-anilino-2',4,4'-trinitrobenzophenone 
• 154010-55-6 2-chloro-6-nitro-9-(2,4-dinitrophenyl)acridine 
• 154010-56-7 2-methyl-6-nitro-9-(2,4-dinitrophenyl)acridine 
• 154010-65-8 3-nitro-9-(2,4-dinitrophenyl)acridine 
• 71642-43-8 3,6-diphenoxy-10-phenylacridin-9-one 
• 166405-61-4 9-phenyl-3,6-bis<(ethoxycarbonyl)amino>acridine 
• 58067-04-2 9-phenyl-acridine-3,6-diamine 
• 351351-75-2 N-[9-(4-dimethylamino-phenylamino)-6-(3-pyrrolidin-1-yl-propionylamino)-acridin-3-yl]-3-pyrrolidin-1-yl-propionamide 

Relevant academic research and scientific papers

Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity

A series of new 3,6,9-trisubstituted acridine derivatives with fluorine substituents on phenyl ring were synthesized and their interaction with calf thymus DNA was investigated. Analysis using UV–Vis absorbance spectra provided valuable information about

Antiprotozoal activity and DNA binding of dicationic acridones

Dicationic acridone derivatives were synthesized and their antiparasitic activity was evaluated. Acridones displayed in vitro nanomolar IC50 values against Trypanosoma brucei rhodesiense STIB900 with selectivity indices >1000. Compounds 1b, 3a,

Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents

The design, synthesis, biophysical and biochemical evaluation is presented of a new series of benzylamino-substituted acridines as G-quadruplex binding telomerase inhibitors. Replacement of the previously reported anilino substituents by benzylamino group

CANCER TREATMENT USING SPECIFIC 3,6,9-SUBSTITUTED ACRIDINES

The present invention relates to a 3,6,9 acridine compound and optionally substituted derivatives thereof that may be useful in the treatment of cancer. The invention also provides compositions comprising the compounds and uses thereof.

Therapeutic acridone and acridine compounds

The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is