351379-48-1

Upstream product

• 88122-12-7 3,4-dihydroxy-2-methylbenzaldehyde 

Downstream Products

• 851121-99-8 5-bromo-3,4-dimethoxy-2-methyl-benzaldehyde 
• 851122-00-4 5-bromo-3,4-dimethoxy-2-methyl-phenol 
• 851121-88-5 {2-(5-allyloxy-1-benzyloxymethyl-4-hydroxy-7,8-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzyl]-2-oxo-ethyl}-methyl-carbamic acid tert-butyl ester 
• 851122-04-8 [2-(5-allyloxy-1-benzyloxymethyl-4-hydroxy-7,8-dimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(3-benzyloxy-2-hydroxymethyl-4-methoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 851121-89-6 [2-(5-allyloxy-1-benzyloxymethyl-7,8-dimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-1-(3-benzyloxy-2-formyl-4-methoxy-5-methyl-benzyl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 851122-06-0 C₄₆H₅₆N₂O₇Si 
• 851121-90-9 C₄₃H₄₆N₂O₈ 
• 851121-96-5 C₃₉H₄₈N₂O₉Si 
• 851122-08-2 C₃₉H₄₆N₂O₉Si 
• 851122-07-1 C₃₉H₄₈N₂O₈Si 
• 851122-05-9 C₄₀H₄₄N₂O₈ 
• 851121-91-0 C₄₀H₄₂N₂O₇ 
• 851121-95-4 C₃₉H₅₀N₂O₇Si 
• 851121-93-2 C₃₂H₃₀N₂O₉ 

Relevant academic research and scientific papers

Synthetic studies on Et-743. Asymmetric, stereocontrolled construction of the tetrahydroisoquinoline core via radical cyclization on a glyoxalimine

The asymmetric synthesis of a highly functionalized tetrahydroisoquinoline relevant to the total synthesis of Et-743 is described. The key step involves a highly diastereoselective radical cyclization on a glyoxalimine derivative.

Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis

(Chemical Equation Presented) A formal total synthesis of the potent anticancer agent Et-743 is described. The tetrahydroisoquinoline core is stereoselectively constructed using a novel radical cyclization of a glyoxalimine. Further elaboration of this core rapidly accessed the pentacyclic core of Et-743, but a mixture of regiosisomers was obtained in the key Pictet-Spengler ring closure. A known advanced intermediate in the synthesis of Et-743 was intercepted, constituting a formal synthesis of the molecule.

Stereospecific formal total synthesis of ecteinascidin 743

(Chemical Equation Presented) A new strategy was designed for the construction of the pentacyclic ring system of ecteinascidin 743. Key features include highly concise routes to the enantiopure, configurationally matched subunit 1, a novel vinylogous Pict

Total synthesis of cribrostatin IV: Fine-tuning the character of an amide bond by remote control

We report the enantioselective total synthesis of cribrostatin IV (1). Key features of this synthesis involve the convergent coupling of two highly functionalized homochiral components followed by a "lynchpin" Mannich cyclization to establish the pentacyc