851122-06-0Relevant articles and documents
Pentacyclic Alkaloid Compounds and Methods of Use Thereof
-
Page/Page column 68, (2010/01/31)
The present invention relates to Pentacyclic Alkaloid Compounds, compositions comprising an effective amount of a Pentacyclic Alkaloid Compound and methods for treating or preventing cancer, a bacterial infection, a fungal infection, or a yeast infection,
Total synthesis of cribrostatin IV: Fine-tuning the character of an amide bond by remote control
Chan, Collin,Heid, Richard,Zheng, Shengping,Guo, Jinsong,Zhou, Bishan,Furuuchi, Takeshi,Danishefsky, Samuel J.
, p. 4596 - 4598 (2007/10/03)
We report the enantioselective total synthesis of cribrostatin IV (1). Key features of this synthesis involve the convergent coupling of two highly functionalized homochiral components followed by a "lynchpin" Mannich cyclization to establish the pentacyc