351380-02-4

Upstream product

• 886450-24-4 [2-(2,2-di-tert-butyl-8-methoxy-7-methyl-4H-benzo[1,3,2]dioxasilin-5-yl)-1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-carbamic acid tert-butyl ester 
• 886450-26-6 [2-(3-benzyloxy-2-hydroxymethyl-4-methoxy-5-methyl-phenyl)-1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-carbamic acid tert-butyl ester 
• 886450-27-7 [2-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-phenyl]-1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-carbamic acid tert-butyl ester 
• 74-88-4 methyl iodide 
• 351377-69-0 5-[2-azido-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-2,2-di-tert-butyl-8-methoxy-7-methyl-4H-benzo[1,3,2]dioxasiline 
• 886450-07-3 3-azido-4-(2,2-di-tert-butyl-8-methoxy-7-methyl-4H-benzo[1,3,2]dioxasilin-5-yl)-butane-1,2-diol 
• 886450-25-5 [1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(3-hydroxy-2-hydroxymethyl-4-methoxy-5-methyl-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 351377-68-9 4-(2,2-di-tert-butyl-8-methoxy-7-methyl-4H-benzo[1,3,2]dioxasilin-5-yl)-but-2-en-1-ol 
• 351377-67-8 2,2-dimethyl-propionic acid 4-(3-hydroxy-2-hydroxymethyl-4-methoxy-5-methyl-phenyl)-but-2-enyl ester 
• 351377-65-6 4-[4-(tert-butyl-dimethyl-silanyloxy)-but-2-enyl]-2-methoxymethoxy-6-methyl-phenol 
• 351377-66-7 2,2-dimethyl-propionic acid 4-(4-methoxy-3-methoxymethoxy-5-methyl-phenyl)-but-2-enyl ester 

Downstream Products

• 351378-20-6 [1-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzyl]-2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 886450-28-8 [1-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzyl]-2-(1-benzyloxymethyl-4-hydroxy-5,7,8-trimethoxy-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 886450-29-9 [1-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzyl]-2-(9-benzyloxymethyl-6-hydroxy-5-methoxy-4-methyl-6,9-dihydro-7H-[1,3]dioxolo[4,5-h]isoquinolin-8-yl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 351378-05-7 [1-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-benzyl]-2-(9-benzyloxymethyl-5-methoxy-4-methyl-6-oxo-6,9-dihydro-7H-[1,3]dioxolo[4,5-h]isoquinolin-8-yl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 351380-06-8 [1-(3-benzyloxy-2-hydroxymethyl-4-methoxy-5-methyl-benzyl)-2-(9-benzyloxymethyl-5-methoxy-4-methyl-6-oxo-6,9-dihydro-7H-[1,3]dioxolo[4,5-h]isoquinolin-8-yl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 351380-08-0 [1-(3-benzyloxy-2-hydroxymethyl-4-methoxy-5-methyl-benzyl)-2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 351378-22-8 [1-(3-benzyloxy-2-formyl-4-methoxy-5-methyl-benzyl)-2-(1-benzyloxymethyl-5,7,8-trimethoxy-6-methyl-4-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 351378-07-9 [1-(3-benzyloxy-2-formyl-4-methoxy-5-methyl-benzyl)-2-(9-benzyloxymethyl-5-methoxy-4-methyl-6-oxo-6,9-dihydro-7H-[1,3]dioxolo[4,5-h]isoquinolin-8-yl)-2-oxo-ethyl]-methyl-carbamic acid tert-butyl ester 
• 351377-62-3 3-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-phenyl]-2-(tert-butoxycarbonyl-methyl-amino)-propionic acid 

Relevant academic research and scientific papers

The solution to a deep stereochemical conundrum: Studies toward the tetrahydroisoquinoline alkaloids

(Chemical Equation Presented) Facile construction of subunits 1 and 2 allowed the rapid assembly of the pentacyclic ring system 3 of the cytotoxic tetrahydroisoquinoline alkaloids. A surprising participation reaction was discovered, which necessitated rev