35143-75-0

Usage

Uses

Used in Pharmaceutical Industry:
5-Isoxazolamine,4-methyl-(9CI) is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structure and properties make it a promising candidate for the creation of novel drugs with potential therapeutic applications.
Used in Research Applications:
In the field of research, 5-Isoxazolamine,4-methyl-(9CI) is utilized as a chemical building block for the synthesis of various organic compounds. Its versatility and reactivity contribute to the advancement of scientific knowledge and the discovery of new chemical entities with potential applications in various industries.
Used in Drug Development:
5-Isoxazolamine,4-methyl-(9CI) is employed as a key component in the development of new drugs and functional materials. Its unique chemical properties allow for the exploration of its potential in creating innovative therapeutic agents and materials with improved efficacy and safety profiles.

Upstream product

• 81621-00-3 2-(4-methyl-5-isoxazolylamine)-N-(4-methyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine 

Downstream Products

• 71565-78-1 2-cyanopropionamide 

Relevant academic research and scientific papers

Reactions of N,N-bis(siloxy)enamines with trimethylsilyl cyanide: Aliphatic nitro compounds as convenient precursors of 5-aminoisoxazoles

A convenient procedure was developed for the synthesis of 5-aminoisoxazoles by the consecutive double silylation and cyanation of aliphatic nitro compounds.

Isoxazoles. VII: Hydrolysis of 4-methyl-5-isoxazolylnaphthoquinone derivatives in aqueous solutions

The kinetics for the degradation of 2-(4-methyl-5-isoxazolylamine)-N-(4-methyl-5-isoxazolyl)-1,4- naphthoquinone-4-imine (1) in solution were investigated at 70 °C and at a constant ionic strength of 0.5 over a pH range of 1.75 to 12.85. The degradation rates were determined by absorption and second-derivative UV spectrometry. Two degradation products were identified in acidic and neutral pHs; they are 4-N-(4-methyl-5-isoxazolyl)-1,2-naphthoquinone (2) and 2-methyl-cyanoacetamide (5), respectively. In alkaline pH, two degradation products, 2-hydroxy-N-(4-methyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine (3) and 5-amino-4-methylisoxazole (4), were isolated. The pathway for degradation of 1 in acidic and neutral pH followed consecutive first-order kinetics since 2 undergoes hydrolysis giving 2-hydroxy-1,4-naphthoquinone (6) and 2-methylcyanoacetamide (5). No appreciable buffer effect on the degradation of 1 and 2 was observed for any of the buffer species in this study. The pH-rate profiles exhibited specific acid and specific basic catalysis for 1 and specific acid catalysis for 2. The maximum stability for 1 and 2 occurred in the neutral pH region.