71565-78-1

Basic information

• Product Name: 2-cyanopropanamide
• CAS NO: 71565-78-1
• Molecular Formula: C₄H₆N₂O
• Molecular Weight: 98.1032
• Mol File: 71565-78-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 305.7°C at 760 mmHg
• Flash Point: 138.7°C
• Density: 1.1g/cm³
• Vapor Pressure: 0.000809mmHg at 25°C
• Refractive Index: 1.451
• CAS DataBase Reference: 2-cyanopropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyanopropanamide(71565-78-1)
• EPA Substance Registry System: 2-cyanopropanamide(71565-78-1)

Safety Data

• Hazardous Substances Data: 71565-78-1(Hazardous Substances Data)

Upstream product

• 1572-99-2 ethyl 2-cyanopropionate 
• 35143-75-0 5-amino-4-methylisoxazole 
• 64-17-5 ethanol 
• 81621-00-3 2-(4-methyl-5-isoxazolylamine)-N-(4-methyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine 
• 81620-96-4 4-N-(4-methyl-5-isoxazolyl)-1,2-naphthoquinone 
• 14618-77-0 methyl 2-cyanopropionate 

Downstream Products

• 3696-36-4 2-methylmalononitrile 
• 29679-10-5 2-Cyano-2-phenylazo-propionamid 
• 957785-28-3 3-methyl-4-[(3,4-dimethoxy-2-phenylmethoxy)phenyl]-6-[(5,6,8-trimethoxy)-2-quinolinyl]-(1H)-2-pyridinone 
• 957785-23-8 C₂₁H₁₆N₂O 
• 83021-65-2 3,6-dimethyl-4-phenylpyridin-2(1H)-one 
• 55854-89-2 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one 
• 7732-18-5 water 

Relevant articles and documents

Total synthesis of streptonigrone

(Chemical Equation Presented) A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substituted pyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approach from previous ones are the use of a Conrad-Limpach reaction, rather than the customary Friedlaender methodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequence for the functionalization of a key pyridone intermediate.

Isoxazoles. VII: Hydrolysis of 4-methyl-5-isoxazolylnaphthoquinone derivatives in aqueous solutions

The kinetics for the degradation of 2-(4-methyl-5-isoxazolylamine)-N-(4-methyl-5-isoxazolyl)-1,4- naphthoquinone-4-imine (1) in solution were investigated at 70 °C and at a constant ionic strength of 0.5 over a pH range of 1.75 to 12.85. The degradation rates were determined by absorption and second-derivative UV spectrometry. Two degradation products were identified in acidic and neutral pHs; they are 4-N-(4-methyl-5-isoxazolyl)-1,2-naphthoquinone (2) and 2-methyl-cyanoacetamide (5), respectively. In alkaline pH, two degradation products, 2-hydroxy-N-(4-methyl-5-isoxazolyl)-1,4-naphthoquinone-4-imine (3) and 5-amino-4-methylisoxazole (4), were isolated. The pathway for degradation of 1 in acidic and neutral pH followed consecutive first-order kinetics since 2 undergoes hydrolysis giving 2-hydroxy-1,4-naphthoquinone (6) and 2-methylcyanoacetamide (5). No appreciable buffer effect on the degradation of 1 and 2 was observed for any of the buffer species in this study. The pH-rate profiles exhibited specific acid and specific basic catalysis for 1 and specific acid catalysis for 2. The maximum stability for 1 and 2 occurred in the neutral pH region.

Kinetic Evidence for the Intermediacy of 1-Azirines in the Gas-Phase Thermal Isomerization of 3H-Isoxazoles to α-Carbonylacetonitrile Derivatives

Thermal isomerization of 5-methylisoxazole and 5-amino-4-methylisoxazole to acetylacetonitrile and 2-cyanopropionamide, respectively, was studied in a flow system.The activation parameters are reported.According to the experimental results, a concerted 1,3 sigmatropic shift to 1-azirines is proposed as the rate-limiting step in these reactions.A general reaction mechanism for the isomerization of isoxazoles into 1-azirines, oxazoles, and α-carbonylacetonitrile derivatives is discussed.