35146-02-2Relevant articles and documents
Preparation method of cytosine intermediate 3,3-diethoxypropionitrile
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Paragraph 0022; 0024, (2017/02/17)
The invention discloses a preparation method of cytosine intermediate 3,3-diethoxypropionitrile. The preparation method comprises following steps: 1) acetonitrile is taken as a raw material, and is reacted with tert-butyl hydroperoxide (TBHP) in the presence of a catalyst, and an obtained product and carbon monoxide are subjected to carbonylation reaction so as to obtain nitrile acetaldehyde; and step 2, nitrile acetaldehyde is reacted with ethanol in the presence of acid alcohol of a catalytic amount so as to obtain 3,3-diethoxypropionitrile. Obtained 3,3-diethoxypropionitrile can be subjected to condensation reaction with urea so as to prepare cytosine, synthesis effect is excellent, and the quality of obtained cytosine is high. Reaction mechanism of the preparation method is different from reaction mechanism of the prior art in which acetonitrile hydrogen protons are captured by strong base; in the preparation method, acetonitrile hydrogen protons are captured via free radical reaction so as to obtain acetonitrile free radicals; the acetonitrile free radicals are subjected to carbonylation reaction with carbon monoxide so as to obtain nitrile acetaldehyde directly; and nitrile acetaldehyde is transformed into 3,3-diethoxypropionitrile in the presence of acid alcohol of a catalytic amount.
